Calcitonin gene-related peptide is a 37 amino-acid vasoactive neuropeptide (MW 3789) widely expressed throughout the central and peripheral nervous system. CGRP has potent vasodilatory effects probably serving as a regulator of regional blood flow, in addition to a variety of other cellular effects. This antibody binds an epitope within the aa 1-18 of human alpha-CGRP. Based on inhibition ELISA, this antibody shows full cross-reactivity with rat alpha-CGRP and about 50% cross-reactivity with human beta-CGRP. Cross-reactivity with coated rat alpha-CGRP is low (8%) and there is no cross-reaction with human amylin.