Rabbit anti-Chicken / Chimpanzee / Human / Monkey NAMPT / Visfatin, serum - IMG-6111A

Background
NAMPT is a 491 amino acid adipokine belonging to the NAPRTase family. It promotes angiogenesis via activation of the mitogen-activated protein kinase ERK-dependent pathway, is upregulated in neutrophils by IL-1beta, and functions as a novel inhibitor of apoptosis in response to a variety of inflammatory stimuli. It acts as a regulator of NAD+-dependent reactions in smooth muscle cells (SMCs) and in the pathogenesis of type 2 diabetes mellitus. NAMPT plays a role in insulin resistance and markers of hyperandrogenism in lean PCOS patients. It is a longevity protein that can add stress-resistant life to human smooth muscle cells by optimizing SIRT1-mediated p53 degradation. The expression level of NAMPT is high in visceral fat and serum levels in overweight and obese subjects with metabolic syndrome. It is expressed in large amounts in bone marrow, liver tissue, muscle, heart, placenta, lung and kidney tissues.

Antigen
A portion of amino acid 30-80 of human NAMPT/Visfatin was used as the immunogen.

Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, monkey, chimpanzee and chicken, and 94% homologous in horse, cow, mouse and rat.

Genebank Info (Protein)
NP_005737

Reference
1. van, E. et al. J. Biol. Chem. 282:10841-10845 (2007).
2. Jia, SH. et al. J. Clin. Invest. 113:1318-1327 (2004).