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Homo sapiens crystallin, alpha A (CRYAA) as transfection-ready DNA - SC300064

Imprimer

CRYAA (NM_000394) Human cDNA Clone

Specifications

Citations

Clones of Other Species

Product Documents

SKU	Description	Availibility*
SC300064	Homo sapiens crystallin, alpha A (CRYAA) as transfection-ready DNA NM_000394.2, 10ug	In Stock
TF81001	TurboFectin, High performance Transfection reagent (1ml/vial)	In Stock
TA505577	Purified CRYAA (Alpha A Crystallin) mouse monoclonal antibody, Clone 3B12, 100ul	In Stock

Also for CRYAA (NM_000394)

OriGene Data

Vector:	pCMV6-XL5	Insert Size: 800	Restriction Site:
Sequence Data:	Fully Sequenced ORF 5' Read Nucleotide Sequence
OTI Annotation:	The ORF of this clone has been fully sequenced and found to be a perfect match to NM_000394.2.
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:
Protein Pathways:

Reference Data

RefSeq: NM_000394.2 , NP_000385	RefSeq Size: 1114	RefSeq ORF: 522
Synonyms : CRYA1; HSPB4
LocusID: 1409	Cytogenetic: 21q22.3
Summary: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jul 2008].

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

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Homo sapiens crystallin, alpha A (CRYAA) as transfection-ready DNA - SC300064

CRYAA (NM_000394) Human cDNA Clone

TrueClone Citations:

CRYAA Mouse Clones

CRYAA Rat Clones

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