FANCD2 (ID 2177) Trilencer-27 Human siRNA
|Catalog No. ||Description || ||Availability* || |
|SR301519 || |
- FANCD2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 2177)
- Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
- Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
| ||In Stock || |
|TT300001 ||SiTran1.0: Transfection reagent designed for RNAi duplex (0.5 ml) |
Free! With the purchase of 2 siRNA kits (save )
| ||In Stock || |
* These siRNA duplexes were designed to be effective against all transcriptional variants at this gene locus.
Also for FANCD2 (Locus ID 2177)
|Amount:||2 nmol each, lyophilized||Purity:||HPLC purified|
|Quality Control:||Tested by ESI-MS||Sequences:||Available with shipment|
|Stability:||One year from date of shipment when stored at -20 ºC||Shipment: Ambient|
|# of transfections:||Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM)|
|RefSeq: NM_001018115 NM_033084 |
|Synonyms: FA-D2; FA4; FACD; FAD; FAD2; FANCD|
|Summary: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. |Performance Guranteed:
OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.
For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at email@example.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping