Rabbit monoclonal antibody against TRAF3(clone EPR1731) - TA307878
Anti-TRAF3 Antibody EPR1731
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Also for TRAF3 (NM_145725)
|A synthetic peptide corresponding to residues in human TRAF3 was used as an immunogen.|
|EPR1731 ||Rabbit IgG |
|Human, Mouse, Rat || |
|WB ||WB: 1:1,000-10,000, |
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens TNF receptor-associated factor 3 (TRAF3), transcript variant 1|
|CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1|
|Human TRAF3 is an adaptor protein and signaling transducer that interacts with the cytoplasmic tails of CD40 and other TNF-receptor family members (1). The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signaling cascades, leading to the activation of NF-kappaB and mitogen-activated protein kinases. Furthermore, TRAF proteins serve as a docking platform for a variety of regulators of these signaling pathways and are themselves often regulated at the transcriptional and posttranslational level (2). Residues shown by mutagenesis and deletion analysis to be critical for TRAF3 binding are involved either in direct contact with TRAF3 or in intramolecular interactions that stabilize the hairpin (3). It is regulated by TANK/ITRAF, which competes with TNFRSF5/CD40 for binding (4).|
Toll-like receptor signaling pathway
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Western blot analysis on (A) Molt-4 and (B) 293T cell lysates using anti-TRAF3 RabMAb .