Rabbit anti-human TRAF3 (Clone : EPR1731)

Anti-TRAF3 Antibody EPR1731

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Also for TRAF3 (NM_145725)

Immunogen	A synthetic peptide corresponding to residues in human TRAF3 was used as an immunogen.
Clone Name	EPR1731	Isotype	Rabbit IgG
Species Reactivity	Human, Mouse, Rat	Concentration
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000-10,000,
Buffer	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Purification	(Protein A or G Sepharose )

Target Name	Homo sapiens TNF receptor-associated factor 3 (TRAF3), transcript variant 1
Alternative Name	CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1
Database Link	NP_663777
Function	Human TRAF3 is an adaptor protein and signaling transducer that interacts with the cytoplasmic tails of CD40 and other TNF-receptor family members (1). The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signaling cascades, leading to the activation of NF-kappaB and mitogen-activated protein kinases. Furthermore, TRAF proteins serve as a docking platform for a variety of regulators of these signaling pathways and are themselves often regulated at the transcriptional and posttranslational level (2). Residues shown by mutagenesis and deletion analysis to be critical for TRAF3 binding are involved either in direct contact with TRAF3 or in intramolecular interactions that stabilize the hairpin (3). It is regulated by TANK/ITRAF, which competes with TNFRSF5/CD40 for binding (4).
Related Pathway	Apoptosis Toll-like receptor signaling pathway

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Western blot analysis on (A) Molt-4 and (B) 293T cell lysates using anti-TRAF3 RabMAb .

Rabbit monoclonal antibody against TRAF3(clone EPR1731) - TA307878