Anti-mouse CD200R3 : basophils and mast cells

Ba103 and Ba91, antibodies recognizing CD200R3 : important new tools to study the mysterious roles of basophils (Cat.# HM1103 and HM1104)

anti-mouse CD200R3

Unique antibodies for functional studies on mouse basophils and mast cells

mAb Ba91 induced degranulation of MC/9 cells. MC/9 cells were incubated with the indicated reagents. Degranulation was calculated by measuring ß-hex osaminidase release.

Other reagents for research on Mouse Leukocytes : Cat# Description HM1039 Ly-6G neutrophil marker, Mouse, mAb NIMP-R14 HM1051 MPO, Mouse, mAb 8F4, cross reactive rat HM1066 F4/80 - Macrophages, Mouse, mAb BM8 HM1070 CD68, Macrosialin, Mouse, mAb FA-11 HM1088 Monocytes, Mouse, mAb ER-HR3 HM1089 M-CSF resp cells, Mouse, mAb ER-MP58 HM1105 CD96 (TACTILE), Mouse, mAb 6A6 HM1106 CD155, Mouse, mAb 3F1 More products for leukocyte markers : click here

• mAb Ba103 is useful for depletion of basophils but not mast cells
• mAb Ba91 and mAb Ba103 added to basophils or mast cells induce degranulation of the cells in vitro
• bulk quantity available of 1 mg (Cat.# HM1103b; HM1104b)

• CD200R3 functions as an activating receptor on mast cells and basophils
• CD200R3 regulates IgE-independent immune responses in cooperation with an inhibitory receptor CD200R
• Basophils are candidate effector cells for the immune response against parasites
• Basophils are a major source of the typical Th2 cytokine IL-4 during parasite infections

1. Kojima, T et al; Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. J Immunol 2007, 179: 7093
2. Obata, K et al; Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 2007, 110: 913
3. Karasuyama, H et al; Newly discovered roles for basophils: a neglected minority gains new respect. Nature Rev Immunol 2009, 9: 9
4. Sullivan, B et al; Basophils: a nonredundant contributor to host immunity. Immunity 2009, 30: 12

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