Cell cycle inhibitors

Members of the Cip/Kip family of cyclin-dependent kinases inhibitors (CKIs) are well characterized for their role as negative regulators of G1-phase cell-cycle progression. >

Cip4, Ras, p21, p27, p57, Kip1, Kip2

Members of the Cip/Kip family of cyclin-dependent kinases inhibitors (CKIs) are well characterized for their role as negative regulators of G1-phase cell-cycle progression.

C9orf86, CDKN2A, p14ARF, p16INK4a, p19ARF, CDKN2AIP, ISOC2, p15 INK4b, p18 INK4c

The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression.

KMT1A, SUV39H1, p105, p107, p130

p53 was the first tumour suppressor gene to be identified.

ALDH1L1, BRCC45, CDCA4, CDKN2AIP, DRAM, GTSE1, HAUSP, USP7, HOXA5, JAB1, MDM2, OVCA1, PARC, PBK, PRMT1, Pirh2, iASPP, p53, p63, p73

Other cell cycle inhibitors.

ARHGAP20, B7H4, BAP1, BIN1, C8orf72, CHFR, CHMP1a, CtBP1, Cullin 1, Cullin 2, Cullin 3, DBC1, DBC2, EB3, ELAC2, ENPP7, ErbB 2, FAT, HRAS, Hamartin, JAK2, Kisspeptin, LKB1, LYK5, LZTS1, MEI1, MLL5, MRG15, MTBP, NEK6, Nck, PHC3, PTCH2, RASSF4, RSL1D1, SCGB3A1, SERTAD2, TSG101, TUSC2, mTOR