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You are here : HOME > Research field > Cardiovascular > Angiogenesis
Angiogenesis
| Angiogenic Factors Tumors induce blood vessel growth (angiogenesis) by secreting various growth factors (e.g. Vascular Endothelial Growth Factor or VEGF).
Growth factors such as bFGF and VEGF can induce capillary growth into the tumor, which some researchers suspect supply required nutrients, allowing for tumor expansion. Angiogenesis is also required for the spread of metastasis. The blood vessel in a given solid tumor may in fact be mosaic vessels, composed of endothelial cells and tumor cells. | | Inhibitors An angiogenesis inhibitor is a substance that inhibits growth of new blood vessels. It can be endogenous or come from outside as drug or a dietary component.
Every solid tumor (in contrast to liquid tumors like leukemia) needs to generate blood vessels to keep it alive once it reaches a certain size. Usually, blood vessels are not built elsewhere in an adult body unless tissue repair is actively in process. The angiostatic agent endostatin and related chemicals can suppress the building of blood vessels, preventing the cancer from growing indefinitely. In tests with patients, the tumor became inactive and stayed that way even after the endostatin treatment was finished. The treatment has very few side effects but appears to have very limited selectivity. |
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