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Adenosine monophosphate [61-19-8]

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Adenosine monophosphate

(Synonyms: AMP, Adenosine 5'-monophosphate, 5'-Adenylic acid) Copy Product Info

Synonyms: AMP, Adenosine 5'-monophosphate, 5'-Adenylic acid

Catalog No. T2133 Copy Product Info

Purity: 99.84%

Adenosine monophosphate (AMP) is a purine ribonucleoside 5'-monophosphates and a key cellular metabolite in signal transduction and regulation of energy homeostasis.It has a role as an EC 3.1.3.11 (fructose-bisphosphatase) inhibitor, an EC 3.1.3.1 (alkaline phosphatase) inhibitor and an adenosine A1 receptor agonist.

Cas No. 61-19-8

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.84%

Appearance:Solid

Color:White

Product Introduction

Adenosine monophosphate AI Summary

Adenosine monophosphate demonstrates a broad spectrum of bioactivities in various biochemical and cellular assays. It prominently exhibits potent inhibitory activity against HIV-1 protease with a low Ki of 0.23 nM, underscores its potential as an HIV therapeutic. Compellingly, it shows agonist potency at P2Y purinoceptors, notably at hP2Y2 with an EC50 of 85.0 nM, which implicates its role in modulating purinergic signaling. The compound is also effective as an inhibitor of several enzymes, such as human recombinant fructose-1,6-bisphosphatase (FBPase), with variable IC50 values across different conditions and substrates. Additionally, it inhibits inosine monophosphate dehydrogenase in Escherichia coli (Ki = 450,000.0 nM), Phosphatidylinositol 4-kinase at 31.3%, and horse liver alcohol dehydrogenase (Ki = 38,000.0 nM). 40940 also shows significant impact on adenylate kinases, AMP aminohydrolase, and AK isozymes, influencing their enzymatic velocities and substrate affinity. Beyond enzymatic inhibition, Adenosine monophosphate also demonstrates antiviral capabilities, especially highlighted by its activity against a range of viruses including Vaccinia, Herpes simplex, and SARS-CoV-2. Notably, it modulates metabolic enzymes like AMPK and displays binding affinity towards various enzymatic and protein targets. The compound’s properties including notable solubility in sodium phosphate buffer, an involvement in purinergic, kinase, and deaminase pathways, and its ability to resist cytotoxicity in several cell lines underscore its multifaceted bioactivity and therapeutic potential across different biological contexts..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Adenosine monophosphate (AMP) is a purine ribonucleoside 5'-monophosphates and a key cellular metabolite in signal transduction and regulation of energy homeostasis.It has a role as an EC 3.1.3.11 (fructose-bisphosphatase) inhibitor, an EC 3.1.3.1 (alkaline phosphatase) inhibitor and an adenosine A1 receptor agonist.
Synonyms	AMP, Adenosine 5'-monophosphate, 5'-Adenylic acid

Chemical Properties

Molecular Weight	347.22
Formula	C₁₀H₁₄N₅O₇P
Cas No.	61-19-8
Smiles	O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(=O)(O)O)[C@H]1O
Relative Density.	2.32 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (460.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8800 mL	14.4001 mL	28.8002 mL	144.0009 mL
5 mM	0.5760 mL	2.8800 mL	5.7600 mL	28.8002 mL
10 mM	0.2880 mL	1.4400 mL	2.8800 mL	14.4001 mL
20 mM	0.1440 mL	0.7200 mL	1.4400 mL	7.2000 mL
50 mM	0.0576 mL	0.2880 mL	0.5760 mL	2.8800 mL
100 mM	0.0288 mL	0.1440 mL	0.2880 mL	1.4400 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

InhibitorinhibitEndogenousMetaboliteEndogenous MetaboliteAdenosine monophosphateAdenosine5'-AMP-activated protein kinase

Related Tags: Adenosine monophosphate chemical structure | Adenosine monophosphate formula | Adenosine monophosphate molecular weight