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Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

Aluminum Hydroxide [21645-51-2]

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Référence HY-B1521-5g

Conditionnement : 5g

Marque : MedChemExpress

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Description	Aluminum Hydroxide is an orally active main form of aluminum used as adjuvant. Aluminum hydroxide-based adjuvant researches include the repository effect, pro-phagocytic effect, and activation of the pro-inflammatory NLRP3 pathway. Aluminum Hydroxide also acts as adjuvant to compensate low inherent immunogenicity of subunit vaccines^[1]^[2].
In Vitro	Aluminum Hydroxide is not recommended to be freezed when used as the vaccine adjuvant to avoid reducing the immunogenicity of the vaccine. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Aluminum Hydroxide Related Antibodies
Solvant et solubilité	In Vitro: H₂O : < 0.1 mg/mL (insoluble) DMSO : < 1 mg/mL (insoluble or slightly soluble) For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time. The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution. Protocol 1 Add each solvent one by one: 0.5% CMC-Na/saline water Solubility: 10 mg/mL (128.21 mM); Suspended solution; Need ultrasonic In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Dosage mg/kg Animal weight (per animal) g Dosing volume (per animal) μL Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments. Calculation results: Working solution concentration: mg/mL
Pureté et documentation	Purity: ≥97.0% Fiche technique (274 KB) SDS (393 KB) COA (249 KB) Instruction de manipulation (2659 KB)
Références	[1]. He P, et al. Advances in aluminum hydroxide-based adjuvant research and its mechanism. Hum Vaccin Immunother. 2015;11(2):477-88. [Content Brief] [2]. Amini Y, et al. Aluminum hydroxide nanoparticles show strong activity to stimulate Th-1 immune response against tuberculosis. Artif Cells Nanomed Biotechnol. 2017 Nov;45(7):1331-1335. [Content Brief] [3]. Ohtawa M, et al. Effect of aluminum ingestion on lipid peroxidation in rats. Chem Pharm Bull (Tokyo). 1983 Apr;31(4):1415-8. [Content Brief]