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> Anti-FGFR2 Antibody (4V380)

Anti-FGFR2 Antibody (4V380)

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Référence NB-64-120125-100uL

Conditionnement : 100uL

Marque : Neo Biotech


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Anti-FGFR2 Antibody (4V380)

(Synonyms: TK25, TK14, K-SAM, KGFR, JWS, FLJ98662, FGFR2 α (IIIb), FGFR2 α, FGFR2 alpha, FGF R2a, ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS) Copy Product Info

Synonyms: TK25, TK14, K-SAM, KGFR, JWS, FLJ98662, FGFR2 α (IIIb), FGFR2 α, FGFR2 alpha, FGF R2a, ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS

Catalog No. TMAH-00431 Copy Product Info
Anti-FGFR2 Antibody (4V380) is an antibody targeting FGFR2. Anti-FGFR2 Antibody (4V380) can be used in ELISA,WB.
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Description
Anti-FGFR2 Antibody (4V380) is an antibody targeting FGFR2. Anti-FGFR2 Antibody (4V380) can be used in ELISA,WB.
SynonymsTK25, TK14, K-SAM, KGFR, JWS, FLJ98662, FGFR2 α (IIIb), FGFR2 α, FGFR2 alpha, FGF R2a, ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS
Ig Type
Rabbit IgG
Clone
4V380
Reactivity
Human, Mouse, Rat
Verified Activity
Western Blot
-Positive WB detected in: Rat Brain whole cell lysate, Rat Lung whole cell lysate, Mouse Brain whole cell lysate
-All lanes: FGFR2 Antibody at 1:1000
-Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
-Predicted band size: 93, 87, 93, 77, 92, 89, 86, 29, 80, 93, 97, 92, 41, 80, 80, 77, 80 kDa
-Observed band size: 145 kDa
Application
ELISA
WB
Recommended Dose
WB:1:500-1:5000.
Antibody Type
Monoclonal
Subcellular LocalizationCell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 8]: Secreted.; [Isoform 13]: Secreted.
ConstructionRecombinant Antibody
PurificationAffinity-chromatography
AppearanceLiquid
FormulationPhosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundTyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
A synthetic peptide: Human FGFR2
Antigen Species
Human
Gene Name
FGFR2
Gene ID
2263
Uniprot ID
P21802
Biology Area
Neuroscience, Cancer, Cardiovascular, Developmental biology, Signal transduction, Stem cells
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Keywords

TK-25TK-14TK 25TK 14FLJ-98662FLJ 98662ECT-1ECT 1CFD-1CFD 1CEK-3CEK 3CD-332CD 332BFR1BFR 1
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