Anti-FGFR2 Antibody (8U49)
Référence NB-64-122770-100uL
Conditionnement : 100uL
Marque : Neo Biotech
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Anti-FGFR2 Antibody (8U49)
(Synonyms: TK25, TK14, K-SAM, KGFR, JWS, fibroblast growth factor receptor 2, FGFR2 α(IIIb), ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS) Copy Product InfoSynonyms: TK25, TK14, K-SAM, KGFR, JWS, fibroblast growth factor receptor 2, FGFR2 α(IIIb), ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS
Catalog No. TMAY-01229 Copy Product Info
Anti-FGFR2 Antibody (8U49) is a Rabbit antibody targeting FGFR2. Anti-FGFR2 Antibody (8U49) can be used in ELISA.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-FGFR2 Antibody (8U49) is a Rabbit antibody targeting FGFR2. Anti-FGFR2 Antibody (8U49) can be used in ELISA. |
| Synonyms | TK25, TK14, K-SAM, KGFR, JWS, fibroblast growth factor receptor 2, FGFR2 α(IIIb), ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS |
| Ig Type | Rabbit IgG |
| Clone | 8U49 |
| Reactivity | Human |
| Specificity | Human FGFR2 No cross-reactivity in ELISA with Human FGFR1 / CD331 Human FGFR4 / CD334 |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human FGFR2 extracellular domain (rh FGFR2; TMPY-01228; NP_000132.3; Met 1-Glu 377). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human FGFR2 protein (TMPY-01228) |
| Antigen Species | Human |
| Biology Area | Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Keywords
TK-25TK-14TK 25TK 14ECT-1ECT 1CFD-1CFD 1CEK-3CEK 3CD-332CD 332BFR1BFR 1
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