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Aromatase inhibitor 23 [32585-54-9]

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Référence NB-64-30461-10mg

Conditionnement : 10mg

Marque : Neo Biotech

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Aromatase inhibitor 23

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Synonyms:

Catalog No. T60006 Copy Product Info

Purity: 99.54%

Aromatase inhibitor 23 is an inhibitor that target protein-protein interactions in RAD51 family of recombinases.

Cas No. 32585-54-9

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.54%

Appearance:Solid

Color:White

Product Information

Aromatase inhibitor 23 AI Summary

Aromatase inhibitor 23 exhibits a diverse range of bioactivities, including modulation of lipid storage in Drosophila S3 cells and identification as a potential general anesthetic through a competitive binding assay. It inhibits chronic active B-cell receptor signaling, ELG1-dependent DNA repair, the malarial parasite plastid, Polymerase Iota, TGF-β, Glutaminase (GLS), the HIV-1 protein Vpr, Vaccinia Orthopoxvirus, and the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). Additionally, it has been screened for antiviral properties against Foot and Mouth Disease Virus. The compound shows cytotoxicity against human MCF7 cells, evident from reduced cell metabolic activity in MTT assays after 24 and 48 hours, and releases LDH in these cells. Furthermore, Aromatase inhibitor 23 exhibits significant inhibition of recombinant human aromatase, with an IC50 value of 200.0 nM and an inhibition percentage of 109.7%. These findings highlight its potential applications in various biological processes and diseases..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aromatase inhibitor 23 is an inhibitor that target protein-protein interactions in RAD51 family of recombinases.

Chemical Properties

Molecular Weight	300.38
Formula	C₁₆H₁₆N₂O₂S
Cas No.	32585-54-9
Smiles	C(CNS(=O)(=O)C1=CC=CC=C1)C=2C=3C(NC2)=CC=CC3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (183.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3291 mL	16.6456 mL	33.2912 mL	166.4558 mL
5 mM	0.6658 mL	3.3291 mL	6.6582 mL	33.2912 mL
10 mM	0.3329 mL	1.6646 mL	3.3291 mL	16.6456 mL
20 mM	0.1665 mL	0.8323 mL	1.6646 mL	8.3228 mL
50 mM	0.0666 mL	0.3329 mL	0.6658 mL	3.3291 mL
100 mM	0.0333 mL	0.1665 mL	0.3329 mL	1.6646 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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