Conditionnement : 1mg
Synonyms:
| Description | Human CRF acetate is a chemical compound that effectively stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary. |
| In vitro | CRF enhances the excitability of type II dlBNST neurons via the activation of the AC-cAMP-PKA pathway, leading to pain-induced aversive responses[1]. |
| In vivo | In rats that received an injection of CRF (1 nmol/side), the duration spent in the drug-paired compartment during the test session (314±22 s) was significantly reduced compared to the time spent in the same compartment during the preconditioning session (520±18 s)[1]. |
| Relative Density. | no data available |
| Sequence | H-{DL-Ser}-{DL-Glu}-{DL-Glu}-{DL-Pro}-{DL-Pro}-{DL-xiIle}-{DL-Ser}-{DL-Leu}-{DL-Asp}-{DL-Leu}-{DL-xiThr}-{DL-Phe}-{DL-His}-{DL-Leu}-{DL-Leu}-{DL-Arg}-{DL-Glu}-{DL-Val}-{DL-Leu}-{DL-Glu}-{DL-Met}-{DL-Ala}-{DL-Arg}-{DL-Ala}-{DL-Glu}-{DL-Gln}-{DL-Leu}-{DL-Ala}-{DL-Gln}-{DL-Gln}-{DL-Ala}-{DL-His}-{DL-Ser}-{DL-Asn}-{DL-Arg}-{DL-Lys}-{DL-Leu}-{DL-Met}-{DL-Glu}-{DL-xiIle}-{DL-xiIle}-NH₂ |
| Sequence Short | SEEPPXSLDLXFHLLREVLEMARAEQLAQQAHSNRKLMEXX |
| Storage | Store under nitrogen,Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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