Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.
 
> CTLA-4 mAb (9D9), InVivoPure

CTLA-4 mAb (9D9), InVivoPure

Imprimer Imprimer
Identifiez-vous

Référence orb2568772-5mg

Conditionnement : 5mg

Marque : Biorbyt


CTLA-4 mAb (9D9), InVivoPure

SKU: orb2568772
This product can be custom made

Description

The CTLA-4 antibody (clone 9D9) is a monoclonal antibody that specifically targets the mouse CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152 [1]. CTLA-4 is a 33 kDa cell surface receptor, belonging to the CD28 family of the immunoglobulin superfamily. CTLA-4 plays a crucial role in immune regulation. 9D9 blocks the binding of murine CTLA-4-Ig to B7-1-positive cells [2]. It has an inhibitory effect and acts as an “off switch” for T cells. It binds to the ligands CD80 and CD86 on antigen-presenting cells (APCs) and thereby inhibits the activation of T cells . The CTLA-4 antibody clone 9D9 has been used to block CTLA-4 and has been shown to enhance T-cell immunity against tumors .

Research Area

Immunology & Inflammation

Images & Validation

−
Tested ApplicationsIn vivo
ReactivityMouse
Application Notes
Recomended Isotype: Mouse IgG2b k Isotype Control, Recomended Isotype Catalog: orb2568791

Key Properties

−
Antibody TypePrimary Antibody
HostMouse
ClonalityMonoclonal
Isotypem IgG2b
Clone No.9D9
ImmunogenUnknown
TargetCTLA-4
Purity≥ 90 % (CGE, reducing conditions) ≤ 10 % aggregates (analytical SEC) Endotoxin level ≤ 2 EU/mg
ConjugationUnconjugated

Storage & Handling

−
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/PreservativesClear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration≥ 1 mg/ mL
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

−
Anti-Mouse CTLA-4, CD152, CTLA4, cytotoxic T-lymphocyte-associated antigen 4, Cytotoxic T-lymphocyte protein 4,
−
    1. CTLA-4 mAb (9D9), InVivoPure+
    2. CTLA-4 mAb (9D9), InVivoPure+

    CTLA-4 mAb (9D9), InVivoPure+ [orb2568771]

    In vivo

    Mouse

    Mouse

    Monoclonal

    Unconjugated

    100 mg, 50 mg, 25 mg, 5 mg, 1 mg

Quick Database Links

Gene Symbol
CTLA-4
UniProt
P09793

UniProt Details

−
No UniProt data available

Protocol Information