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D-Cycloserine [68-41-7]

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Référence NB-64-07085-500mg

Conditionnement : 500mg

Marque : Neo Biotech

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D-Cycloserine

(Synonyms: RO-1-9213) Copy Product Info

Synonyms: RO-1-9213

Catalog No. T1589 Copy Product Info

Purity: 99.98%

D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with other antituberculosis agents.

Cas No. 68-41-7

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Color:White

Product Introduction

D-Cycloserine AI Summary

D-Cycloserine exhibits a broad spectrum of bioactivities, with notable antimicrobial, antimycobacterial, and antiviral properties. It shows strong antibacterial activity against various bacterial strains including Escherichia coli and Staphylococcus aureus, with minimum inhibitory concentrations (MIC) ranging from as low as 0.25 μg/mL to 128.0 μg/mL. Specifically, it is highly effective against Escherichia coli ATCC 9637 with MIC values of 0.25 μg/mL and 0.5 μg/mL. The compound also displays significant inhibitory activity against Mycobacterium tuberculosis strains, including drug-resistant isolates, with MIC50 values around 5.0 μg/mL and MIC90 values of 24,500 nM. Furthermore, D-Cycloserine demonstrates potent antiviral activity, notably against SARS-CoV-2, showing significant inhibition of virus-induced cytotoxicity in VERO-6 cells at various tested concentrations. Additionally, it exhibits moderate efficacy in inhibiting the NMDA receptor with IC50 and EC50 values in the nanomolar range. Despite some hepatotoxicity indications, the compound shows promise in medical applications, particularly for treating infections caused by antibiotic-resistant bacteria and tuberculosis strains, as well as certain viral infections like COVID-19..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with other antituberculosis agents.
Synonyms	RO-1-9213

Chemical Properties

Molecular Weight	102.09
Formula	C₃H₆N₂O₂
Cas No.	68-41-7
Smiles	N[C@H]1C(=O)NOC1
Relative Density.	1.278 g/cm3

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 6.66 mg/mL (65.24 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

Saline: 10.1 mg/mL (98.93 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	9.7953 mL	48.9764 mL	97.9528 mL	489.7639 mL
5 mM	1.9591 mL	9.7953 mL	19.5906 mL	97.9528 mL
10 mM	0.9795 mL	4.8976 mL	9.7953 mL	48.9764 mL
20 mM	0.4898 mL	2.4488 mL	4.8976 mL	24.4882 mL
50 mM	0.1959 mL	0.9795 mL	1.9591 mL	9.7953 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

tuberculosispeptidoglycanNMDAmultidrug-resistantIonotropic glutamate receptorsInhibitorinhibitiGluRD-CycloserineDCycloserineD-alanine--D-alanine ligase AD CycloserinecognitivebiosynthesisBacterialAntibiotic

Related Tags: D-Cycloserine chemical structure | D-Cycloserine formula | D-Cycloserine molecular weight