Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

D-(+)-Trehalose [99-20-7]

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Référence T2O2798-500mg

Conditionnement : 500mg

Marque : TargetMol

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D-(+)-Trehalose

(Synonyms: Trehalose, Mycose, Ergot Sugar, D-Trehalose, D-(+)-Trehalose Anhydrous) Copy Product Info

D-(+)-Trehalose (Mycose) can inhibit the decomposition of collagen, so it can be used to improve osteoporosis.

Cas No. 99-20-7

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:99.82%

Color:White

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COA HNMR LCMS

Product Information

D-(+)-Trehalose AI Summary

D-(+)-Trehalose demonstrates a multifaceted bioactivity profile, including potential neuroprotective effects in R6/2 transgenic mice, where it significantly increased the mean survival time to 94.5 days at a 1% oral concentration, albeit with a 25.0% body weight loss after 12 weeks, indicating some toxicity concerns. The compound notably inhibits amyloid beta-40 and amyloid beta (1 to 42) aggregation across various structural forms (unordered, beta-turns, beta-sheets, alpha-helix) and concentrations, as well as reduces amyloid beta-40-induced cell death in C57BL/6 mouse primary cortical neurons. Additionally, D-(+)-Trehalose shows inhibitory activity against various T6PP enzymes from different organisms, with the highest activity against Brugia malayi T6PP. It exhibits antiviral properties against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells, with moderate inhibition of SARS-CoV-2 3CL-Pro protease at 20µM. The compound also demonstrates a binding affinity to Mycobacterium tuberculosis LpqY, with a dissociation constant (Kd) of 36100.0 nM, and shows weak inhibitory activity against human HDAC6. These diverse bioactivities suggest that D-(+)-Trehalose could be a promising candidate for further research and development in various therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-(+)-Trehalose (Mycose) can inhibit the decomposition of collagen, so it can be used to improve osteoporosis.
Synonyms	Trehalose, Mycose, Ergot Sugar, D-Trehalose, D-(+)-Trehalose Anhydrous

Chemical Properties

Molecular Weight	342.30
Formula	C₁₂H₂₂O₁₁
Cas No.	99-20-7
Smiles	O([C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
Relative Density.	1.76 g/cm3

Storage & Solubility Information

Storage

Store under nitrogen, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 200 mg/mL (584.28 mM)

DMSO: 247.5 mg/mL (723.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 10 mg/mL (29.21 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9214 mL	14.6071 mL	29.2141 mL	146.0707 mL
5 mM	0.5843 mL	2.9214 mL	5.8428 mL	29.2141 mL
10 mM	0.2921 mL	1.4607 mL	2.9214 mL	14.6071 mL
20 mM	0.1461 mL	0.7304 mL	1.4607 mL	7.3035 mL
50 mM	0.0584 mL	0.2921 mL	0.5843 mL	2.9214 mL
100 mM	0.0292 mL	0.1461 mL	0.2921 mL	1.4607 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.