DiscoveryProbe™ Epigenetics Compound Library
Référence L1029-100
Conditionnement : 100uL/well(10mMsolution),96WellRacksWithScrewCap
Marque : APExBIO Technology
- 1. Anna M Schreiber, Yanjie Li, et al. "Selected Histone Deacetylase Inhibitors Reverse the Frataxin Transcriptional Defect in a Novel Friedreich’s Ataxia Induced Pluripotent Stem Cell-Derived Neuronal Reporter System." Front Neurosci. 2022 Feb 23;16:836476. PMID: 35281493
- 2. E Alexis Flores-Padilla, K Eurídice Juárez-Mercado, et al. "Chemoinformatic Characterization of Synthetic Screening Libraries Focused on Epigenetic Targets." Mol Inform. 2022 Jun;41(6):e2100285. PMID: 34931466
- 3. Diana L Prado-Romero, José L Medina-Franco. "Advances in the Exploration of the Epigenetic Relevant Chemical Space." ACS Omega. 2021 Aug 23;6(35):22478-22486. PMID: 34514220
- 4. Jennifer Zhang, Oscar Hou-In Chou, et al. "Application of Patient-Specific iPSCs for Modelling and Treatment of X-Linked Cardiomyopathies." Int J Mol Sci. 2021 Jul 29;22(15):8132. PMID: 34360897
| Catalog No. | Product Name | Summary | Targets | CAS Number | Smiles |
| A3692 | OTX-015 | BRD inhibitor | Bromodomain | 202590-98-5 | CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NC4=CC=C(C=C4)O)C5=CC=C(C=C5)Cl)C |
| A4093 | ITF2357 (Givinostat) | HDAC inhibitor | HDAC | 732302-99-7 | CCN(CC)CC1=CC2=C(C=C(COC(NC3=CC=C(C(NO)=O)C=C3)=O)C=C2)C=C1.O.Cl |
| A4138 | Tofacitinib (CP-690550,Tasocitinib) | Janus kinase inhibitor | JAK | 477600-75-2 | CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N |
| A4166 | EPZ5676 | DOT1L inhibitor,potent and SAM competitive | Histone Methyltransferase | 1380288-87-8 | CC(C)N(CC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C |
| A8708 | Sephin1 | Selective PPP1R15A inhibitor | Protein Ser/Thr Phosphatases | 13098-73-2 | ClC1=CC=CC=C1/C=N/NC(N)=N |
| A8712 | MCB-613 | stimulator of steroid receptor coactivator (SRC) | Histone Acetyltransferases | 1162656-22-5 | O=C(/C(CN(CC)C/1)=C/C2=CC=CN=C2)C1=C\C3=CN=CC=C3 |
| B1499 | RVX-208 | Potent BET bromodomain inhibitor | Bromodomain | 1044870-39-4 | CC1=CC(=CC(=C1OCCO)C)C2=NC(=O)C3=C(C=C(C=C3N2)OC)OC |
| B4891 | ML324 | JMJD2 demethylase inhibitor, potent and cell-permeable | Histone Demethylases | 1222800-79-4 | OC1=CC(C2=CC=C(C(NCCCN(C)C)=C)C=C2)=CC3=CC=CN=C31 |
Related Biological Data
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| Form | Pre-dissolved DMSO solutions | Stability | Solution: -20°C for 12 months, -80°C for 24 months |
| Packaging | 96-well rack with Matrix 2D Barcoded ScrewTop Storage tubes (250 μL or 100 μL/well, 10 mM DMSO). 96-well DeepWell format with peelable foil seal and EVA cap (100 μL/well, 10 mM DMSO). | ||
| Shipping Condition | Evaluation sample solution: ship with blue ice All other available size: ship with RT, or blue ice upon request | ||
Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation
-- Available in stock with overnight delivery and free shipping over $500.
-- Cost-effective and competitive price to save your budget.
-- Potent, selective and cell-permeable in inhibiting or activating target molecules.
-- Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
-- Detailed files describing potency, selectivity and applications etc.
-- Supported by published data from top peer-reviewed journals.
-- Guaranteed high quality with NMR and HPLC validation.