Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

Epimedokoreanin B [161068-53-7]

Imprimer

Référence NB-64-64520-1mL

Conditionnement : 1mLx10mM(inDMSO)

Marque : Neo Biotech

Demander plus d'informations

Epimedokoreanin B

Catalog No. TN3972 Copy Product Info

Purity: 99.75%

Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-inflammatory and antibacterial activities, and may have scavenging activity against DPPH radicals, inhibiting the proliferation of MCF-7 and HepG2 in a dose-dependent manner. Epimedokoreanin B also exhibits anti-inflammatory and antibacterial activity, with DPPH radical scavenging activity, and inhibits the proliferation of MCF-7 and HepG2 in a dose-dependent manner.Epimedokoreanin B significantly inhibits the formation of N (Î±)-(carboxymethyl)lysine (CML) and N (Ï)-(carboxymethyl)arginine (CMA), and prevents clinical complications of diabetes mellitus through the inhibition of advanced glycation end-products (AGEs).

Epimedokoreanin B

Copy Product Info

Cas No. 161068-53-7

Customer service consultation

Batch Information

Select Batch

Purity:99.75%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-inflammatory and antibacterial activities, and may have scavenging activity against DPPH radicals, inhibiting the proliferation of MCF-7 and HepG2 in a dose-dependent manner. Epimedokoreanin B also exhibits anti-inflammatory and antibacterial activity, with DPPH radical scavenging activity, and inhibits the proliferation of MCF-7 and HepG2 in a dose-dependent manner.Epimedokoreanin B significantly inhibits the formation of N (Î±)-(carboxymethyl)lysine (CML) and N (Ï)-(carboxymethyl)arginine (CMA), and prevents clinical complications of diabetes mellitus through the inhibition of advanced glycation end-products (AGEs).
Targets&IC50	HNE:6.06 μM, Bacterial Nucleic Acid:0.17 µM
In vitro	Epimedokoreanin B (compound6) (3.13-25 μM; 48 h) showed significant inhibitory effects on the proliferation of lung cancer cells A549, Calu1, and H1299. Epimedokoreanin B is non-toxic to human bronchial epithelial cells BEAS-2B.[1] Epimedokoreanin B (5 μM; 24 h) inhibits CD163 expression and IL-10 production, a known M2 marker, indicating that Epimedokoreanin B inhibits M2 polarization in human monocyte-derived macrophages (HMDM). Epimedokoreanin B inhibits STAT3 activation in HMDMs.[4] Epimedokoreanin B treatment inhibits cell proliferation and migration accompanied by cytoplasmic vacuolation in A549 and NCI-H292 cells. Autophagosome accumulation accompanied by blockage of autophagic flux was observed in Epimedokoreanin B-treated cells, consistent with the occurrence of endoplasmic reticulum stress.[2]

Chemical Properties

Molecular Weight	422.47
Formula	C₂₅H₂₆O₆
Cas No.	161068-53-7
Smiles	C(C=C(C)C)C1=C2C(C(=O)C=C(O2)C3=CC(CC=C(C)C)=C(O)C(O)=C3)=C(O)C=C1O
Relative Density.	1.301 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33.33 mg/mL (78.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3670 mL	11.8352 mL	23.6703 mL	118.3516 mL
5 mM	0.4734 mL	2.3670 mL	4.7341 mL	23.6703 mL
10 mM	0.2367 mL	1.1835 mL	2.3670 mL	11.8352 mL
20 mM	0.1184 mL	0.5918 mL	1.1835 mL	5.9176 mL
50 mM	0.0473 mL	0.2367 mL	0.4734 mL	2.3670 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.