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Ezatiostat TFA

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Référence NB-64-30258-10mg

Conditionnement : 10mg

Marque : Neo Biotech

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Ezatiostat TFA

(Synonyms: TER199(free base), Ezatiostat TFA (free base)) Copy Product Info

Synonyms: TER199(free base), Ezatiostat TFA (free base)

Catalog No. T5862 Copy Product Info

Purity: 98.74%

Ezatiostat TFA (TLK199) is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.74%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	Ezatiostat TFA (TLK199) is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity.
In vitro	Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity (Ki = 400 nM) with minimal effect on the related GSTα and -μ families (Kis range from 20-75 μM)[1].
Synonyms	TER199(free base), Ezatiostat TFA (free base)

Chemical Properties

Molecular Weight	643.67
Formula	C₂₉H₃₆F₃N₃O₈S
Smiles	OC(C(F)(F)F)=O.CCOC([C@@H](N)CCC(N[C@@H](CSCC1=CC=CC=C1)C(N[C@H](C2=CC=CC=C2)C(OCC)=O)=O)=O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (38.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5536 mL	7.7680 mL	15.5359 mL	77.6796 mL
5 mM	0.3107 mL	1.5536 mL	3.1072 mL	15.5359 mL
10 mM	0.1554 mL	0.7768 mL	1.5536 mL	7.7680 mL
20 mM	0.0777 mL	0.3884 mL	0.7768 mL	3.8840 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

TLK-199TLK 199GSTPEzatiostat TFA

Related Tags: Ezatiostat TFA chemical structure | Ezatiostat TFA in vitro | Ezatiostat TFA formula | Ezatiostat TFA molecular weight