FLI1 Antibody

Référence MBS856264-0,1mL-PE

Conditionnement : 0.1mL(PE)

Marque : MyBiosource


FLI1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS856264

MBS856264 is an antibody targeting FLI1. Also known as FLI1 Antibody. Reactive in Human, Mouse. More details

Product Overview

Online Datasheet in PDF
Product Name
FLI1, Antibody
Full Product Name
FLI1 Antibody
Product Gene Name
anti-FLI1 antibody
Product Synonym Names
EWSR2; SIC-1; FLI1/EWS FUSION GENE; VIRAL INTEGRATION REGION FLI1; MOUSE HOMOLOG OF EWING SARCOMA BREAKPOINT REGION 2
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
FLI1 antibody detects endogenous levels of total FLI1 protein.
Preparation and Storage
Store at-20 degree C for 1 year
Molecular Weight
29,084 Da
OMIM
193067
3D Structure
ModBase 3D Structure for Q01543
Immunogen
The antiserum was produced against synthesized peptide derived from human FLI1.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-FLI1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-FLI1 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000

Immunohistochemistry (IHC) of anti-FLI1 antibody

Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FLI1 antibody.
Anti-FLI1 Antibody – Cat# MBS856264

Western Blot (WB) of anti-FLI1 antibody

Western blot analysis of extracts from NIH/3T3 cells, using FLI1 antibody.
Anti-FLI1 Antibody, Western Blot (WB) – Cat# MBS856264

Product References and Citations for anti-FLI1 antibody

Hana Raslova, J. Clin. Invest., Jul 2004; 114: 77-84. Jeffrey A. Toretsky, Cancer Res., Jun 2006; 66: 5574-5581. Masahide Kubo, Am. J. Pathol., Aug 2003; 163: 571. Sashidhar S. Nakerakanti, J. Biol. Chem., Sep 2006; 281: 25259-25269.

Other Notes

Small volumes of anti-FLI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FLI1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
Friend leukemia integration 1 transcription factor isoform 2
NCBI Official Synonym Full Names
Fli-1 proto-oncogene, ETS transcription factor
NCBI Official Symbol
FLI1
NCBI Official Synonym Symbols
EWSR2; SIC-1; BDPLT21
UniProt Protein Name
Friend leukemia integration 1 transcription factor
UniProt Synonym Protein Names
Proto-oncogene Fli-1; Transcription factor ERGB
Protein Family
Friend leukemia integration 1 transcription factor
UniProt Gene Name
FLI1
NCBI Protein Information
Friend leukemia integration 1 transcription factor

NCBI Summary for FLI1

This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Show more

UniProt Comments for FLI1

Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FLI1 antibody

 Reference Product  PubMed Publications
 EWSR1 antibody  >398 publications with FLI1 and EWSR1
 ERG antibody  >126 publications with FLI1 and ERG
 GATA1 antibody  >28 publications with FLI1 and GATA1
 ETV6 antibody  >9 publications with FLI1 and ETV6
 TGFBR2 antibody  >6 publications with FLI1 and TGFBR2
 SRF antibody  >4 publications with FLI1 and SRF
 KLF1 antibody  >2 publications with FLI1 and KLF1
 TDP2 antibody  >1 publications with FLI1 and TDP2

Pathways associated with anti-FLI1 antibody

 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with anti-FLI1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >580 publications with FLI1 and Neoplasms
 Sarcoma, Ewing Antibodies  >457 publications with FLI1 and Sarcoma, Ewing
 Carcinoma Antibodies  >48 publications with FLI1 and Carcinoma
 Disease Models, Animal Antibodies  >33 publications with FLI1 and Disease Models, Animal
 Kidney Diseases Antibodies  >30 publications with FLI1 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >30 publications with FLI1 and Neoplasms, Experimental
 Fibrosis Antibodies  >20 publications with FLI1 and Fibrosis
 Brain Diseases Antibodies  >17 publications with FLI1 and Brain Diseases
 Necrosis Antibodies  >14 publications with FLI1 and Necrosis
 Congenital Abnormalities Antibodies  >11 publications with FLI1 and Congenital Abnormalities

Organs/Tissues associated with anti-FLI1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >277 publications with FLI1 and Bone
 Blood Antibodies  >172 publications with FLI1 and Blood
 Vascular Antibodies  >98 publications with FLI1 and Vascular
 Bone Marrow Antibodies  >52 publications with FLI1 and Bone Marrow
 Embryonic Tissue Antibodies  >39 publications with FLI1 and Embryonic Tissue
 Kidney Antibodies  >35 publications with FLI1 and Kidney
 Brain Antibodies  >29 publications with FLI1 and Brain
 Muscle Antibodies  >28 publications with FLI1 and Muscle
 Lung Antibodies  >22 publications with FLI1 and Lung
 Nerve Antibodies  >19 publications with FLI1 and Nerve