Immunohistochemistry. Immunocytochemistry. Suitable for Frozen or Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections and cell smears: 1/50-1/200 using streptavidin~biotin system or polymer system. Recommended Positive Control:Human brain or astrocytoma.
Reactivity
Bovine, Guinea Pig, Human, Mouse, Porcine, Rat
Antibody Host
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
Purified Human GFAP.
Specificity
This antibody stains astrocytes, glial cells, ependymal cells and their corresponding tumors. In the peripheral nervous system , it stains Schwann cells, satellite and enteric glial cells. This antibody distinguishes neoplasm of astrocytes origin from other neoplasm of CNS. Cellular Localization: Cytoplasmic.
Gilial Fibrillary acidic protein (GFAP), a 51 kDa an intermediate filament protein is closely related to non-epithelial family members, Vimentin, desmin and peripherin, which are all involved in structure and function of cell cytoskeleton. GFAP is expressed in central nervous system (CNS) in the astrocytes cells, functioning in cellular processes e.g. cell structure, movements, cell communication, brain processes and brain functions.
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