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Glutathione oxidized [27025-41-8]

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Glutathione oxidized

(Synonyms: Oxidized glutathione, L-Glutathione oxidized, L(-)-Glutathione, GSSG, Glutathione disulfide, Bi(glutathion-S-yl)) Copy Product Info

Synonyms: Oxidized glutathione, L-Glutathione oxidized, L(-)-Glutathione, GSSG, Glutathione disulfide, Bi(glutathion-S-yl)

Catalog No. T1085L Copy Product Info

Purity: 99.96%

Glutathione oxidized (L(-) -glutathione) is the oxidized form of Glutathione, which is a major antioxidant and antidote in cells. Glutathione oxidized can be used to study sickle cells and red blood cells.

Cas No. 27025-41-8

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Appearance:Solid

Color:White

Product Introduction

Glutathione oxidized AI Summary

Glutathione oxidized exhibits a range of inhibitory activities across different biological systems and assays. It shows potent inhibitory activity against glutathione reductase in the presence of NADPH, with a Km value of 114,700.0 nM. The compound also modulates human MRP2-mediated estradiol-17-beta-glucuronide transport with an activity level of 136.0% relative to control in Sf9 cells inverted membrane vesicles and inhibits MRP1 with a Km value of 93,000.0 nM. Additionally, Glutathione oxidized acts as an inhibitor in various bioassays: it inhibits Tau fibril formation and Thioflavin T binding with potencies ranging from 19,952.6 nM to 39,810.7 nM; Bacillus subtilis Sfp phosphopantetheinyl transferase with potencies from 44,668.4 nM to 100,000.0 nM; and fructose-1,6-bisphosphate aldolase from Giardia Lamblia with a potency of 1,990.5 nM. It also inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells, with a potency of 23,715.0 nM. In antibacterial applications, Glutathione oxidized shows activity against both metronidazole-resistant and metronidazole-susceptible strains of Helicobacter pylori, with varying Km values indicating higher affinity in the susceptible strains (ranging from 2,300,000 nM to 4,900,000 nM) compared to the resistant ones (ranging from 3,000,000 nM to 5,200,000 nM). However, Glutathione oxidized exhibits no measurable inhibitory activity against wild type recombinant human histone lysine methyltransferase G9a or GLP, with an IC50 value greater than 100,000.0 nM for both enzymes. Lastly, it demonstrated bioactivity in reducing cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), with an inhibition index of 1.297, surpassing the activity of the control (arbidol)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Glutathione oxidized (L(-) -glutathione) is the oxidized form of Glutathione, which is a major antioxidant and antidote in cells. Glutathione oxidized can be used to study sickle cells and red blood cells.
Targets & IC50	[3H]-AMPA:0.8-15.9 μM
In vitro	METHODS: Sickle erythrocytes were treated with Glutathione oxidized (10 μmol/L) for 0, 90, 150, and 210 minutes to detect the difference in GSH concentration between intracellular and extracellular. RESULTS: Increased efflux of Glutathione oxidized causes glutathione depletion and may impair the antioxidant defense of sickle erythrocytes. [1]
In vivo	METHODS: To study the effect of Glutathione oxidized on brain injury, Glutathione oxidized (100 mM) was injected into wild type mice. RESULTS: Glutathione oxidized causes significant brain damage in wild type mice. [2]
Synonyms	Oxidized glutathione, L-Glutathione oxidized, L(-)-Glutathione, GSSG, Glutathione disulfide, Bi(glutathion-S-yl)

Chemical Properties

Molecular Weight	612.63
Formula	C₂₀H₃₂N₆O₁₂S₂
Cas No.	27025-41-8
Smiles	[C@@H](NC(CC[C@@H](C(O)=O)N)=O)(C(NCC(O)=O)=O)CSSC[C@H](NC(CC[C@@H](C(O)=O)N)=O)C(NCC(O)=O)=O
Relative Density.	1.54g/cm3

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 1.39 mg/mL (2.27 mM), Sonication is recommended.

H2O: 165 mg/mL (269.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.6323 mL	8.1615 mL	16.3231 mL	81.6153 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.3265 mL	1.6323 mL	3.2646 mL	16.3231 mL
10 mM	0.1632 mL	0.8162 mL	1.6323 mL	8.1615 mL
20 mM	0.0816 mL	0.4081 mL	0.8162 mL	4.0808 mL
50 mM	0.0326 mL	0.1632 mL	0.3265 mL	1.6323 mL
100 mM	0.0163 mL	0.0816 mL	0.1632 mL	0.8162 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

ReactiveOxygenSpeciesReactive Oxygen SpeciesOxiglutationeLGlutathioneInhibitorinhibitGlutathionereductaseGlutathione reductaseGlutathione oxidizedGlutathione DisulfideGlutathioneEndogenousMetaboliteEndogenous Metabolite

Related Tags: Glutathione oxidized chemical structure | Glutathione oxidized in vivo | Glutathione oxidized in vitro | Glutathione oxidized formula | Glutathione oxidized molecular weight