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Grp94 Inhibitor-1 [2234897-35-7]

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Référence NB-64-40553-50mg

Conditionnement : 50mg

Marque : Neo Biotech

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Grp94 Inhibitor-1

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Synonyms:

Catalog No. T7261 Copy Product Info

Purity: 98.83%

Grp94 Inhibitor-1 is a potent and selective inhibitor of Grp94 with an IC50 of 2 nM.

Cas No. 2234897-35-7

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.83%

Appearance:Solid

Color:White

Product Introduction

Grp94 Inhibitor-1 AI Summary

Grp94 Inhibitor-1 exhibits potent bioactivity related to its binding affinity and inhibition properties on chaperone proteins HSP90alpha and GRP94. It demonstrates high binding affinity to both human HSP90alpha and dog GRP94 proteins, with Kd values around 20,000 nM. The compound shows strong inhibition of FITC-geldanamycin binding to the dog GST-tagged GRP94 protein, achieving an IC50 value of 2.0 nM and complete inhibition at a concentration of 100 uM. Additionally, the compound achieves 100% inhibition of both dog GRP94 and HSP90alpha at the same concentration. Grp94 Inhibitor-1 has favorable pharmacokinetic properties, including a logD value of 4.59, adequate aqueous solubility at 3.9 ug/mL, high permeability at pH 7.4, and stable metabolic characteristics in both mouse and human microsomes. These activities suggest that Grp94 Inhibitor-1 may have potential as a modulator of HSP90alpha and GRP94 protein interactions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Grp94 Inhibitor-1 is a potent and selective inhibitor of Grp94 with an IC50 of 2 nM.
Targets & IC50	Grp94:2 nM

Chemical Properties

Molecular Weight	352.47
Formula	C₂₂H₂₈N₂O₂
Cas No.	2234897-35-7
Smiles	CC(C)c1ccc(cc1)-c1ccc(N[C@H]2CC[C@H](O)CC2)c(c1)C(N)=O
Relative Density.	1.165 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (236.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8371 mL	14.1856 mL	28.3712 mL	141.8560 mL
5 mM	0.5674 mL	2.8371 mL	5.6742 mL	28.3712 mL
10 mM	0.2837 mL	1.4186 mL	2.8371 mL	14.1856 mL
20 mM	0.1419 mL	0.7093 mL	1.4186 mL	7.0928 mL
50 mM	0.0567 mL	0.2837 mL	0.5674 mL	2.8371 mL
100 mM	0.0284 mL	0.1419 mL	0.2837 mL	1.4186 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

integrin αLintegrin α2InhibitorinhibitHSPHeat shock proteinsGrp94 Inhibitor-1Grp-94 Inhibitor-1Grp94 Inhibitor1Grp94 Inhibitor 1Grp94

Related Tags: Grp94 Inhibitor-1 chemical structure | Grp94 Inhibitor-1 formula | Grp94 Inhibitor-1 molecular weight