Orb1307056-25mg | Heparan Sulfate [9050-30-0] Clinisciences

Heparan Sulfate

SKU: orb1307056

Description

Heparan sulfate is a linear polysaccharide proteoglycan (HSPG) bound to cell surfaces and the extracellular matrix. It is widely used in research on angiogenesis, viral entry mechanisms, and growth factor signaling in both cellular and animal studies.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	9050-30-0
MW	593.47(monomer)
Formula	C₁₂H₁₉NO₂₀S₃ (monomer)
SMILES	6.CO[C@@H]1OC(COS(O)(=O)=O)[C@H](O[C@@H]2OC([C@H](O[C@@H]3OC(COS(O)(=O)=O)[C@H](O[C@@H]4OC([C@H](OC)[C@H](O)[C@@H]4OS(O)(=O)=O)C(O)=O)[C@H](O)[C@@H]3NS(O)(=O)=O)[C@H](O)[C@@H]2O)C(O)=O)[C@H](OS(O)(=O)=O)[C@@H]1NS(O)(=O)=O
Target	FGFR\|\|\|Endogenous Metabolite\|\|\|Wnt/beta-catenin
Solubility	H2O:100 mg/mL;DMSO:Insoluble

Bioactivity

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Target IC50	MCF-10A cells (AR-induced mitogenesis):2 μg/mL\|RBD:0.02 μg/mL
In Vivo	METHODS: To assay anti-tumor activity in vivo, Heparan sulfate (0.8 mg/kg) was administered to SCID-hu mice injected with bone marrow aspirates from myeloma patients twice daily, once intraperitoneally and once subcutaneously, for four weeks. RESULTS: Treatment with Heparan sulfate significantly inhibited primary tumor growth in a human severe combined immunodeficiency (SCID-hu) myeloma model.
In Vitro	METHODS: Breast cancer cells MDA-MB231 were treated with Heparan sulfate (20 µg/mL) for 24 h and detected by Fluorescence microscopy. RESULTS: Cell spreading was enhanced and the average spreading cell area approximately doubled in the presence of Heparan sulfate. Exogenous Heparan sulfate blocked cell invasion and matrix degradation.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Wnt/β-catenin, Wnt/betacatenin, Wnt, Wnt/b-catenin, βcatenin, beta-catenin, betacatenin, bcatenin, inhibit, Inhibitor, Heparan, Heparan Sulfate, EndogenousMetabolite, Endogenous Metabolite, Fibroblast growth factor receptor, FGFR, Human Endogenous Metabolite

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Applications:
FC, IF, IHC-P, WB
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