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> HMG1 (HMGB1) Rabbit Polyclonal Antibody

HMG1 (HMGB1) Rabbit Polyclonal Antibody

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Référence TA301448

Conditionnement : 100ul


HMG1 (HMGB1) Rabbit Polyclonal Antibody

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SKU
TA301448
Rabbit Polyclonal Antibody against HMGB1 - Oligodendrocyte Marker
Size:
100 ul
Conjugation:
Unconjugated
 

View other "HMG1 or NM_002128" antibodies

Specifications
Product Data
Application ELISA, FC, ICC/IF, IHC, Simple Western, WB
Recommended Dilution Simple Western: 1:2000, Flow Cytometry: 1:100, Flow (Intracellular), ELISA, Western Blot: 0.5-1.0 ug/ml, Immunocytochemistry/ Immunofluorescence: 0.05 ug/ml, Immunohistochemistry: 1:100-1:250, Immunohistochemistry-Paraffin: 1:100-1:250, Knockdown Validated
Reactivity Bovine, Dog, Hamster, Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide made to an internal portion of the human HMGB1 protein sequence (between residues 100-200). UniProt #P09429
Buffer Tris-glycine, 150mM NaCl and 0.1% sodium azide
Purification Affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name high mobility group box 1
Database Link
Background HMGB1 and HMGB2 are part of the chromatin non-histone high mobility group proteins 1 and 2. These proteins (containing multiple HMG-boxes) are conserved domains of 80 amino acids which mediate the DNA binding of many proteins. HMG box domains recognize DNA structure. Both HMGB1 and HMGB2 contain an N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of these proteins contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMGB1 and HMGB2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites. They may also serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription, and replication.
Synonyms HMG1; HMG3; SBP-1
Reference Data
Protein Categories Chemokines, Cytokines, Intracellular Proteins, Secreated Proteins
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways Base excision repair
Product Manuals
FAQs
  • Antibody and Western Standard
SDS

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