Human BLNK Antibody : APC (Phospho-Tyr84)
Référence OAAQ00173-100tests
Conditionnement : 100Tests
Marque : Aviva Systems Biology
Human BLNK Antibody : APC (Phospho-Tyr84)
Human BLNK Antibody : APC (Phospho-Tyr84) (OAAQ00173)
| Datasheets/Manuals | Printable datasheet for OAAQ00173 |
|---|
| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Mouse, Rat |
| Product Format | Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA. |
| Clonality | Monoclonal |
| Clone | BLNKY84-H4 |
| Isotype | Rabbit IgG1k |
| Host | Rabbit |
| Conjugation | APC: Allophycocyanin |
| Application | FC |
| Reconstitution and Storage | 2-8C |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr84 of human phospho BLNK |
| Purification | Protein A+G |
| Target Post-Translational Modification | Phospho-Tyr84 |
| Application Info | For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Reference | Fu, C., et al. (1998) Immunity 9: 93-103. Goitsuka, R., et al. (1998) J. Immunol. 161: 5804-5808. Tsuji, S., et al. (2001) J. Exp. Med. 194: 529-539. |
|---|---|
| Gene Symbol | BLNK |
| Gene Full Name | B cell linker |
| Alias Symbols | bca, AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65 |
| NCBI Gene Id | 29760 |
| Protein Name | B-cell linker protein |
| Description of Target | This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. |
| Uniprot ID | Q8WV28 |
| Protein Accession # | NP_001107566.1 |
| Nucleotide Accession # | NM_001114094.1 |
