Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

Imipenem (monohydrate) [74431-23-5]

Imprimer

Référence HY-B1369-100mg

Conditionnement : 100mg

Marque : MedChemExpress

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Description

Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections^[1]^[2]^[3].

IC₅₀ & Target

β-lactam

In Vivo

Imipenem monohydrate (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent^[3].
Pharmacokinetic Parameters of Imipenem monohydrate in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single)^[1].

₅₀

Drug and dose(mg/kg)	C_max(mg/liter)	T_max(min)	AUC_tot(mg ? min/liter)	V_z/F(ml/kg)	V_ss/F (ml/kg)	CL/F(ml/min/kg)	t_1/2(min)	MRT(min)
Imipenem
8	15 (7.1)	21 (11)	1,470 (777)	648 (330)	721 (343)	6.7 (3)	67 (11)	108 (12)
16	34 (6)	28 (18)	2,857 (559)	507 (140)	543 (121)	5.8 (1)	60 (9.1)	94 (10)
32	54 (11)	18 (6.1)	4,895 (635)	516 (75)	566 (83)	6.6 (0.8)	54 (6.5)	86 (11)
64	69 (37)	15 (9.5)	6,037 (2,976)	547 (274)	617 (308)	7.4 (3.6)	43 (22)	70 (35)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Neutropenic mouse model of biofilm lung infection^[3]
Dosage:	4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
Administration:	4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
Result:	Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.

Essai clinique

Masse moléculaire

317.36

Formule

C₁₂H₁₉N₃O₅S

CAS No.

74431-23-5

Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(C(N12)=C(SCCNC=N)C[C@]2(08)[C@@H]([C@H](O)C)C1=O)O.O

Structure Classification

Initial Source

Microorganisms

Streptomyces cattleya

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvant et solubilité

In Vitro:

H₂O : 6.25 mg/mL (19.69 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1510 mL	15.7550 mL	31.5100 mL
5 mM	0.6302 mL	3.1510 mL	6.3020 mL
10 mM	0.3151 mL	1.5755 mL	3.1510 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 10 mg/mL (31.51 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureté et documentation

Purity: 99.90%

Fiche technique (279 KB) SDS (393 KB)

COA (250 KB) HNMR (252 KB) RP-HPLC (276 KB) MS (71 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Johann Motsch, et al. RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections. Clin Infect Dis. 2020 Apr 15;70(9):1799-1808. [Content Brief]

[2]. Wang Hengzhuang, et al. In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection. Antimicrob Agents Chemother. 2012 May;56(5):2683-90 [Content Brief]

[3]. F P Tally, et al. In vitro activity of N-formimidoyl thienamycin (MK0787). Antimicrob Agents Chemother. 1980 Oct;18(4):642-4. [Content Brief]

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