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Inobrodib [2222941-37-7]

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Référence NB-64-01928-1mL

Conditionnement : 1mLx10mM(inDMSO)

Marque : Neo Biotech

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Inobrodib

(Synonyms: CCS1477, CBP-IN-1) Copy Product Info

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Synonyms: CCS1477, CBP-IN-1

Catalog No. T10717 Copy Product Info

Purity: 99.84%

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Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain.

Cas No. 2222941-37-7

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.84%

Appearance:Solid

Color:White

Product Introduction

Inobrodib AI Summary

Inobrodib demonstrates antiviral activity against SARS-CoV-2 induced cytotoxicity in VERO-E6 cells, although it did not show a significant inhibitory effect at a concentration of 10 µM, with an IC50 value exceeding 100,000 nM. This compound also exhibited moderate cytotoxicity against VERO-E6 cells with a CC50 value of 3160 nM. Additionally, Inobrodib shows potent inhibitory activity against the human CBP bromodomain with an IC50 value of 2.05 nM and a dissociation constant (Kd) of 14.0 nM. It exhibits antiproliferative activities against various human cancer cell lines, including LNCaP C4-2B (IC50 = 1650.0 nM), LNCaP (IC50 = 60.0 nM), and 22Rv1 (IC50 = 420.0 nM) by inhibiting cell growth. The compound also affects the thermal stability of various bromodomains, as evidenced by changes in melting temperatures in thermal shift assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain.
Synonyms	CCS1477, CBP-IN-1

Chemical Properties

Molecular Weight	534.6
Formula	C₃₀H₃₂F₂N₄O₃
Cas No.	2222941-37-7
Smiles	CO[C@H]1CC[C@@H](CC1)n1c(nc2cc(ccc12)-c1c(C)noc1C)[C@@H]1CCCC(=O)N1c1ccc(F)c(F)c1
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (187.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8706 mL	9.3528 mL	18.7056 mL	93.5279 mL
5 mM	0.3741 mL	1.8706 mL	3.7411 mL	18.7056 mL
10 mM	0.1871 mL	0.9353 mL	1.8706 mL	9.3528 mL
20 mM	0.0935 mL	0.4676 mL	0.9353 mL	4.6764 mL
50 mM	0.0374 mL	0.1871 mL	0.3741 mL	1.8706 mL
100 mM	0.0187 mL	0.0935 mL	0.1871 mL	0.9353 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

prostateproliferationp300/CBPoralnudemiceInobrodibInhibitorinhibithistonesEpigeneticReaderDomainEpigenetic Reader DomainCCS-1477CCS 1477cancerbromodomain

Related Tags: Inobrodib chemical structure | Inobrodib formula | Inobrodib molecular weight