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> Insulin aspart [116094-23-6]

Insulin aspart [116094-23-6]

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Référence HY-108767-300U

Conditionnement : 300U

Marque : MedChemExpress


Description

Insulin aspart (B28Asp) is a rapid-acting h-Insulin (HY-P0035) analog. Insulin aspart induces a faster hypoglycemic effect. Insulin aspart can be used in diabetes-related research[1][2].

In Vivo

Insulin aspart (5 IU/kg; subcutaneous injection; once daily for 5 consecutive days) exerts a stable hypoglycemic effect in streptozotocin (HY-13753)-induced diabetic mice, and fails to induce significant phosphorylation of hepatic Akt[2].
Insulin aspart (5 IU/kg; subcutaneous injection; single dose) produces sustained and stable systemic hyperinsulinemia in both male and female non-diabetic mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 6−8 weeks old, streptozotocin-induced diabetic)[2]
Dosage: 5 IU/kg
Administration: s.c.; once daily; 5 consecutive days
Result: Boosted plasma insulin levels in fed diabetic mice to 127.6 μIU/mL, with elevation persisting for only 2 h.
Caused a sharp decrease in blood glucose levels in fasted diabetic mice to 109.5 mg/dL at 1 h postinjection, indicating hypoglycemia risk.
Did not induce noticeable hepatic Akt phosphorylation.
Exhibited consistent glycemic control efficacy on Days 1, 2, and 5, with blood glucose-lowering effects comparable to oral casNP/insulin/C10 at 50 IU/kg but with a shorter duration of action.
Animal Model: (male, female, nondiabetic)[2]
Dosage: 5 IU/kg
Administration: s.c.; single dose
Result: In male nondiabetic mice, reached an initial insulin level of 2,053 μIU/mL at baseline, increased modestly to 2,429 μIU/mL at 15 min, then declined to 1,500−1,650 μIU/mL over 1 to 4 h before rising slightly to 1,801 μIU/mL at 8 h.
In female nondiabetic mice, peaked at 2,506 μIU/mL at 1 h, followed by a gradual decline, yet maintained elevated levels of 1,942 μIU/mL at 8 h.
Essai clinique
Formule

C256H381N65O79S6
CAS No.
Appearance

Liquid

Color

Colorless to off-white

Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Store at 4°C, do not freeze
Pureté et documentation
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