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> Interleukin-6 / IL6 (30-212, His-Tag) Human Protein

Interleukin-6 / IL6 (30-212, His-Tag) Human Protein

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Référence AR09233PU-L

Conditionnement : 500ug


Interleukin-6 / IL6 (30-212, His-Tag) Human Protein

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SKU
AR09233PU-L
Recombinant human IL-6 protein
 

Other products for "IL6 or NM_000600"

Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
VPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
Tag His-Tag
Predicted MW 23.1 kDa (204aa) confirmed by MALDI-TOF
Concentration 0.5mg/ml (determined by Bradford assay)
Purity > 95% by SDS-PAGE
Presentation State Purified
Buffer Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Bioactivity Measured in a cell proliferation assay using TF-1 human erythroleukemic cell. The ED50 range ≤ 0.8ng/ml.
Endotoxin < 1 EU per 1ug of protein (determined by LAL method)
Preparation Liquid purified protein
Recommended Dilution SDS-PAGE, Bioactivity
Protein Description Recombinant interleukin-6, fused to His-tag, was expressed in E.coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Storage Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Reference Data
RefSeq NP_000591.1
Locus ID 3569
UniProt ID P05231
Cytogenetics 7p15.3
Synonyms Interleukin-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor, Interferon beta-2, IFN-beta-2, IFNB2, HGF, HSF
Summary This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). provided by RefSeq, Aug 2020
Protein Categories Allergies and autoimmune diseases, Chemokines, Cytokines, Growth Factors, Intracellular Proteins, Membrane Proteins, Secreated Proteins
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Jak-STAT signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prion diseases, Toll-like receptor signaling pathway
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Référence
Description
Cond.
Prix HT
NB-02-0965
Interleukin-6 (IL-6)
 1mg