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K-8012 [1346513-17-4]

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Référence NB-64-13498-1mg

Conditionnement : 1mg

Marque : Neo Biotech

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K-8012

(Synonyms: K8012, K 8012) Copy Product Info

Synonyms: K8012, K 8012

Catalog No. T24240 Copy Product Info

Purity: 99.72%

K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.

Cas No. 1346513-17-4

Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.72%

Appearance:Solid

Color:Orange

Product Introduction

K-8012 AI Summary

K-8012 exhibits a binding affinity to the human GST-tagged RXRalpha ligand binding domain. This was specifically evaluated through the inhibition of 9-cis-RA-induced coactivator recruitment using a TR-FRET assay, which yielded an IC50 value of 10,000 nM for the compound..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.
Synonyms	K8012, K 8012

Chemical Properties

Molecular Weight	374.45
Formula	C₂₃H₂₃FN₄
Cas No.	1346513-17-4
Smiles	C(=C/1\C=2C(C(CCC=3NN=NN3)=C1C)=CC(F)=CC2)\C4=CC=C(C(C)C)C=C4
Relative Density.	1.223 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (160.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6706 mL	13.3529 mL	26.7058 mL	133.5292 mL
5 mM	0.5341 mL	2.6706 mL	5.3412 mL	26.7058 mL
10 mM	0.2671 mL	1.3353 mL	2.6706 mL	13.3529 mL
20 mM	0.1335 mL	0.6676 mL	1.3353 mL	6.6765 mL
50 mM	0.0534 mL	0.2671 mL	0.5341 mL	2.6706 mL
100 mM	0.0267 mL	0.1335 mL	0.2671 mL	1.3353 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

RXRRetinoidReceptorretinoid X receptor αRetinoid ReceptorRARK-8012

Related Tags: K-8012 chemical structure | K-8012 formula | K-8012 molecular weight