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L-Thyroxine [51-48-9]

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Référence NB-64-01025-500mg

Conditionnement : 500mg

Marque : Neo Biotech

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L-Thyroxine

(Synonyms: T4, NSC 36397, Levothyroxine) Copy Product Info

Synonyms: T4, NSC 36397, Levothyroxine

Catalog No. T0864 Copy Product Info

Purity: 99.56%

L-Thyroxine (NSC 36397) is the major hormone derived from the thyroid gland. L-Thyroxine (NSC 36397) is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. L-Thyroxine (NSC 36397) is released from thyroglobulin by proteolysis and secreted into the blood. L-Thyroxine (NSC 36397) is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

Cas No. 51-48-9

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.56%

Product Introduction

L-Thyroxine AI Summary

L-Thyroxine exhibits a wide range of biological activities, with notable binding affinity and bioactivity across several assays. It has a relative binding affinity of 100.0 when compared to L-T4 in prealbumin binding assays and demonstrates a moderate to strong binding energy of 10.3 kCal mol-1. The compound shows potential in inhibiting TTR-mediated fibrillogenesis with an IC50 value of 10500 nM and demonstrates high activity in promoting angiogenesis, evident in fertilized chicken egg membranes and Matrigel plug assays. In transporter assays, L-Thyroxine acts as both an inhibitor and substrate, with varying Km values in different cell models, indicating interactions with multiple transporters like OATPs and OCT1. It also affects the uptake of thyroxine and triiodothyronine in Xenopus laevis oocytes. In terms of antiviral activities, it shows some inhibition against SARS-CoV-2 in different cell lines, although the effectiveness varies. Regarding enzymatic activity, L-Thyroxine does not exhibit significant activity towards human UGT enzymes but does show moderate inhibition towards human HDAC6. It also affects specific cell signaling pathways and receptors, including PPARgamma, RXRalpha, THRalpha, and THRbeta, and demonstrates selective inhibition towards certain viral entry mechanisms and enzymes like PDE4D. The compound indicates no observable liver toxicity in specific assays but displays moderate hepatotoxicity in others, suggesting nuanced interactions depending on context and conditions. The bioactivities of L-Thyroxine suggest potential therapeutic applications, but further research is needed to fully understand its mechanisms and effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-Thyroxine (NSC 36397) is the major hormone derived from the thyroid gland. L-Thyroxine (NSC 36397) is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. L-Thyroxine (NSC 36397) is released from thyroglobulin by proteolysis and secreted into the blood. L-Thyroxine (NSC 36397) is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
Synonyms	T4, NSC 36397, Levothyroxine

Chemical Properties

Molecular Weight	776.87
Formula	C₁₅H₁₁I₄NO₄
Cas No.	51-48-9
Smiles	N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
Relative Density.	2.635g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (119.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2872 mL	6.4361 mL	12.8722 mL	64.3608 mL
5 mM	0.2574 mL	1.2872 mL	2.5744 mL	12.8722 mL
10 mM	0.1287 mL	0.6436 mL	1.2872 mL	6.4361 mL
20 mM	0.0644 mL	0.3218 mL	0.6436 mL	3.2180 mL
50 mM	0.0257 mL	0.1287 mL	0.2574 mL	1.2872 mL
100 mM	0.0129 mL	0.0644 mL	0.1287 mL	0.6436 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Thyroidhormonereceptor(THR)ThyroidhormonereceptorThyroid hormone receptor(THR)Thyroid Hormone ReceptorThyroid hormoneTHRT-4T 4NSC-36397NSC36397L-ThyroxineLThyroxineL ThyroxineInhibitorinhibitEndogenousMetaboliteEndogenous Metabolite

Related Tags: L-Thyroxine chemical structure | L-Thyroxine formula | L-Thyroxine molecular weight