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> Leptin Protein, Mouse, Recombinant

Leptin Protein, Mouse, Recombinant

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Référence NB-64-52486-500ug

Conditionnement : 500ug

Marque : Neo Biotech


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Leptin Protein, Mouse, Recombinant

(Synonyms: OBS, Obesity Factor, Obese Protein, OB, Leptin, LEP) Copy Product Info

Synonyms: OBS, Obesity Factor, Obese Protein, OB, Leptin, LEP

Catalog No. TMPJ-00052 Copy Product Info
Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin deficient mice are less active and with lower body temperature than normal animals. Human Leptin shares approximately 84% sequence identity with the mouse protein. Human Leptin consists of 167 amino acid residue including a 21 amino acid residue signal sequence and 146 amino acid residue mature protein sequence.
Other Forms of Leptin Protein, Mouse, Recombinant:
Leptin Protein, Carassius auratus, Recombinant (His)
Leptin Protein, Mouse, Recombinant (hFc)
CDH11 Protein, Human, Recombinant (aa 54-617, His)
Leptin Protein, Human, Recombinant
Leptin Protein, Mouse, Recombinant (mFc)
LEP(116-130)(mouse)
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
Appearance:Lyophilized powder
Color:White
Contact us for more batch information

Product Introduction

Bioactivity
Bioactivity
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin deficient mice are less active and with lower body temperature than normal animals. Human Leptin shares approximately 84% sequence identity with the mouse protein. Human Leptin consists of 167 amino acid residue including a 21 amino acid residue signal sequence and 146 amino acid residue mature protein sequence.
Species
Mouse
Expression System
E. coli
TagTag Free
Accession NumberQ544U0
Amino AcidVal22-Cys167
ConstructionVal22-Cys167
Protein Purity
Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
Leptin Protein, Mouse, Recombinant,Leptin Protein, Mouse, Recombinant
Endotoxin< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 300 mM NaCl, pH7.5.
ReconstitutionReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
SynonymsOBS, Obesity Factor, Obese Protein, OB, Leptin, LEP
Research Background
Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin deficient mice are less active and with lower body temperature than normal animals. Human Leptin shares approximately 84% sequence identity with the mouse protein. Human Leptin consists of 167 amino acid residue including a 21 amino acid residue signal sequence and 146 amino acid residue mature protein sequence.
Chemical Properties
Molecular Weight14 KDa (reducing condition)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageLyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Related Tags: Leptin Protein, Mouse, Recombinant chemical structure | Leptin Protein, Mouse, Recombinant molecular weight