Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

Loganic acid [22255-40-9]

Imprimer

Référence NB-64-37954-10mg

Conditionnement : 10mg

Marque : Neo Biotech

Demander plus d'informations

Loganic acid (Synonyms: Loganate)

Catalog No. T6S1440 Copy Product Info

Purity: 99.45%

1. Loganic acid (Loganate) and geniposide exhibit both sides effect on superoxide generation.

Loganic acid

Copy Product Info

Synonyms Loganate

1. Loganic acid (Loganate) and geniposide exhibit both sides effect on superoxide generation.

Cas No. 22255-40-9

Batch Information

Select Batch

Purity:99.45%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Loganic acid AI Summary

Loganic acid exhibits antiviral activity against HCV by inhibiting viral entry and replication in human Huh7 cells, with inhibition percentages of 39.4% and 52.5% at different time points, and an IC50 value of 11.0 µg/mL in inhibiting viral replication after 72 hours by NS5A staining. Additionally, this compound shows significant inhibitory activity in both OATP1B1 and OATP1B3-transfected CHO cells, with 49.18% inhibition of sodium fluorescein uptake in OATP1B1 cells and 99.49% inhibition in OATP1B3 cells at a concentration of 10 µM. Furthermore, Loganic acid exhibits inhibitory activity on both COX1 and COX2 enzymes, showing moderate inhibition of COX1 with percentages between 36.0% and 36.9% at 10 µM and 35 µM concentrations, and potent inhibition of COX2 with inhibition percentages between 80.8% and 84.0% at the same concentrations, though this activity significantly decreases to ≤30.0% at 100 µM. These characteristics suggest that Loganic acid has multifaceted bioactivity with potential applications in antiviral therapy and enzyme inhibition..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Loganic acid (Loganate) and geniposide exhibit both sides effect on superoxide generation.
Synonyms	Loganate

Chemical Properties

Molecular Weight	376.36
Formula	C₁₆H₂₄O₁₀
Cas No.	22255-40-9
Smiles	02[C@]12C[C@H](O)[C@H](C)[C@@]1(02)[C@H](O[C@]1(02)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)OC=C2C(O)=O
Relative Density.	1.6g/cm3

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (664.26 mM), Sonication is recommended.

Ethanol: Soluble

Pyridine, Methanol, etc.: Soluble

H2O: 1 g/mL, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6570 mL	13.2852 mL	26.5703 mL	132.8515 mL
5 mM	0.5314 mL	2.6570 mL	5.3141 mL	26.5703 mL
10 mM	0.2657 mL	1.3285 mL	2.6570 mL	13.2852 mL
20 mM	0.1329 mL	0.6643 mL	1.3285 mL	6.6426 mL
50 mM	0.0531 mL	0.2657 mL	0.5314 mL	2.6570 mL
100 mM	0.0266 mL	0.1329 mL	0.2657 mL	1.3285 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.