Meglutol [503-49-1]
Référence T1664-50mg
Conditionnement : 50mg
Marque : TargetMol
Meglutol
(Synonyms: Dicrotalic acid, 3-Hydroxy-3-methylglutaric acid) Copy Product Info
Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethyl glutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate-limiting enzyme in the biosynthesis of cholesterol.
Cas No. 503-49-1
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.94%
Color:White
COA LCMS HNMR
Product Information
Meglutol AI Summary
Meglutol demonstrates a range of biological activities and interactions. It exhibits no inhibition of rat liver HMG-CoA reductase at a concentration of 10e-3 M in vitro. However, at 0.005 M, it shows moderate inhibition (12.0%) of [14C]acetate incorporation into cholesterol with low inhibition (<10.0%) in the incorporation of [14C]acetate into CO2 and long-chain fatty acids. Despite a strong inhibitory constant (Ki = 23.5 nM) and an IC50 value of 4000.0 nM for HMG-CoA reductase, it is noteworthy that it demonstrates diverse pharmacological effects, including hypoglycemic and antihypercholesterolemic activities in mice and humans, respectively. Additionally, Meglutol manifests toxicity towards brine shrimp and mice with reported LD50 values. In the context of antiviral activity, it shows inhibitory effects on SARS-CoV-2, with a low inhibition rate at 20µM. It further demonstrates antagonist and agonist activities at human receptors TBXA2R, CHRM1, and ADRA1A with AC50 values of 13842.0 nM, 9867.1 nM, and 17972.1 nM respectively. However, for other targets, no significant interactions were observed with AC50 values greater than 30000.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethyl glutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate-limiting enzyme in the biosynthesis of cholesterol. |
| Synonyms | Dicrotalic acid, 3-Hydroxy-3-methylglutaric acid |
| Molecular Weight | 162.1406 |
| Formula | C6H10O5 |
| Cas No. | 503-49-1 |
| Smiles | CC(O)(CC(O)=O)CC(O)=O |
| Relative Density. | 1.417 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 100.00 mg/mL (616.75 mM), Sonication is recommended.  DMSO: 250.00 mg/mL (1541.87 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (12.33 mM), Sonication is recommended. 10% DMSO+90% Saline: 10.00 mg/mL (61.67 mM), Solution. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||