Mucin 4 (8G7)
Référence sc-53945
Conditionnement : 100µg/ml
Marque : Santa Cruz Biotechnology
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Anticorps Mucin 4/MUC4 (8G7): sc-53945
- L'anticorps Mucin 4/MUC4 8G7 est un monoclonal IgG1 de souris, cité dans 59 publications, fourni en 100 µg/ml
- raised against a synthetic peptide directed against the Mucin 4 tandem repeats of human origin
- recommandé pour la détection de Mucin 4 d'origine human par WB, IP, IF et IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mucin 4/MUC4 Antibody (8G7). This work is in progress.
ACCÈS RAPIDE AUX LIENS
, Mucin 12, Mucin 13, Mucin 15, Mucin 16, Mucin 2, Mucin 3, Mucin 5AC, Mucin 5B et Mucin 6
Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 4, a membrane-bound mucin, is the human homolog of the rat sialomucin complex (SMC). Mucin 4 protein consists of Mucin 4α, a large amino mucin type subunit, and Mucin 4β, a transmembrane subunit containing three EGF-like domains. The Mucin 4 gene is the predominant mucin gene expressed in the normal urothelium and is also expressed in several normal tissues such as trachea, lung and testis. Dysregulation of Mucin 4 results in high levels of expression in pancreatic tumors and tumor cell lines. Induction of Mucin 4 in pancreatic carcinoma by all-trans-retinoic acid is mediated through the retinoic acid receptor-α signaling pathway. TGFβ2 serves as an interim mediator of this regulated expression. Alternative splicing in the 3′-end of the Mucin 4 gene generates at least 12 splice variants, which are characterized as two distinct types, a secreted type and a membrane-associated type. Mucin 4 protein acts as a heterodimeric bifunctional cell-surface glycoprotein and forms thick mucous effusion in the diseased middle ear.
Espèces | Nom du Gène | Gene ID | Localisation chromosomique | Numéro d'accession de l'isoforme (ARNm) | Numéro d'accès aux protéines | Numéro OMIM™ |
---|---|---|---|---|---|---|
Human | MUC4 | Entrez Gene ID: 4585 | 3q29 | NM_004532, NM_018406, NM_138297, NM_138298, NM_138299 | UniProt ID: Q99102 | 158372 |
L'anticorps Mucin 4/MUC4 préféré est l'Anticorps Mucin 4/MUC4 (1G8): sc-33654.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Mucin 4/MUC4 (8G7) | sc-53945 | 100 µg/ml | .00 |
Can I freeze this antibody for long term storage?
Has Mucin 4 (8G7): sc-53945 been tested for Flow Cytometry (FCM)?
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