N-Acetylneuraminic acid [131-48-6]
Référence T1638-1g
Conditionnement : 1g
Marque : TargetMol
N-Acetylneuraminic acid
(Synonyms: NeuAc, Lactaminic acid, Acide aceneuramique) Copy Product Info
N-Acetylneuraminic acid (Acide aceneuramique) is a nine-carbon sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies have shown that N-Acetylneuraminic acid is biologically useful for neurotransmission, leukocyte extravasation, viral or bacterial infections, and carbohydrate-protein recognition.
Cas No. 131-48-6
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.97%
Appearance:Solid
Color:White
COA HNMR LCMS
Product Introduction
N-Acetylneuraminic acid AI Summary
N-Acetylneuraminic acid exhibits a range of inhibitory and bioactive properties. It has been tested for inhibition of Influenza sialidase type A and type B, with an IC50 of 1000000.0 nM in both assays, indicating potential but low-level inhibitory effects. The compound is effective in several bioassays: - It counters cytotoxicity in the Nrf2 qHTS screen with a potency of 651.3 nM. - It inhibits Importin-beta complex formation in the Rango assay with a potency of 125892.5 nM. - It inhibits HP1-beta Chromodomain interactions with methylated histone tails with a potency of 89125.1 nM. - It demonstrates inhibitory activity against Hepatitis C Virus (HCV) with a potency of 3162.3 nM. - It exhibits antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells (16.52% inhibition at 10 µM after 48 hours) and against the SARS-CoV-2 3CL-Pro protease (41.21% at 20 µM). However, the compound shows lower efficacy in inhibiting SARS-CoV-2 cytotoxicity in VERO-6 cells, with IC50 values above 50100.0 nM. Additionally, N-Acetylneuraminic acid moderately inhibits human HDAC6 (-21.56% using a commercial peptide substrate) but shows no significant inhibition against human NEU1, NEU2, NEU3, and NEU4, with IC50 values greater than 500000.0 nM. The compound also has a dissociation constant (pKa) of 3.2. Further studies are necessary to fully understand its bioactivity and therapeutic potential..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | N-Acetylneuraminic acid (Acide aceneuramique) is a nine-carbon sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies have shown that N-Acetylneuraminic acid is biologically useful for neurotransmission, leukocyte extravasation, viral or bacterial infections, and carbohydrate-protein recognition. |
| Synonyms | NeuAc, Lactaminic acid, Acide aceneuramique |
| Molecular Weight | 309.27 |
| Formula | C11H19NO9 |
| Cas No. | 131-48-6 |
| Smiles | [C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)([C@H](CC(C(O)=O)=O)O)NC(C)=O |
| Relative Density. | 1.3580 g/cm3 (Estimated) |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 125 mg/mL (404.18 mM), Sonication is recommended.  DMSO: 122 mg/mL (394.48 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||