Phosphoinositide 3 Kinase, p110 gamma, Recombinant, Human (PI3K)
Référence MBS635708-0,01mg
Conditionnement : 0.01mg
Marque : MyBiosource
Phosphoinositide 3 Kinase, P110 Gamma (PIK3R6) Active Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS635708PI3Kg is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3Kg-/- mice showed a reduced ability to respond to chemokines, and had a selective defect… More details
Product Overview
Online Datasheet in PDFProduct Name
Phosphoinositide 3 Kinase, p110 gamma (PIK3R6), Active Protein
Full Product Name
Phosphoinositide 3 Kinase, p110 gamma, Recombinant, Human (PI3K)
Product Gene Name
PIK3R6 active protein
Host
Sf9 insect cells
Form/Format
Supplied as a liquid in 25mM Tris-HCl, pH 8.0, 50mM sodium chloride, 0.5mM MgCl2, 50% glycerol.
Purity/Purification
Highly Purified
95% (SDS-PAGE)
95% (SDS-PAGE)
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
126.3kD without Tag
Chromosome Location
Chromosome: 17; NC_000017.10 (8706055..8770994, complement). Location: 17p13.1
OMIM
611462
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
~ 4.5 nmol/mg/min using phosphatidylinositol as the substrate.
Product Categories/Family for PIK3R6 active protein
Molecular Biology; MB-Protein Kinases
Other Notes
Small volumes of PIK3R6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for PIK3R6 purchase
MBS635708 is an active protein targeting PIK3R6. Also known as Phosphoinositide 3 Kinase, p110 gamma, Recombinant, Human (PI3K). Host: Sf9 insect cells.
Additional Details
NCBI/Uniprot data below describe general gene information for PIK3R6. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
phosphoinositide 3-kinase regulatory subunit 6
NCBI Official Synonym Full Names
phosphoinositide-3-kinase, regulatory subunit 6
NCBI Official Symbol
PIK3R6
NCBI Official Synonym Symbols
p84; C17orf38; HsT41028; p87PIKAP; p84 PIKAP; p87(PIKAP)
UniProt Protein Name
Phosphoinositide 3-kinase regulatory subunit 6
UniProt Synonym Protein Names
Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; p84 PI3K adapter protein; p84 PIKAP; p87 PI3K adapter protein
Protein Family
Phosphoinositide 3-kinase regulatory
UniProt Gene Name
PIK3R6
UniProt Synonym Gene Names
C17orf38; p84 PIKAP; p87PIKAP
UniProt Entry Name
PI3R6_HUMAN
NCBI Protein Information
phosphoinositide 3-kinase regulatory subunit 6; p84 PI3K adapter protein; PI3Kgamma adapter protein of 87 kDa; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
NCBI Summary for PIK3R6
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for PIK3R6
PIK3R6: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS1 bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: membrane; cytosol
Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity
Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; positive regulation of MAP kinase activity; positive regulation of angiogenesis; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; angiogenesis; blood coagulation; regulation of phosphoinositide 3-kinase activity
Show more Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: membrane; cytosol
Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity
Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; positive regulation of MAP kinase activity; positive regulation of angiogenesis; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; angiogenesis; blood coagulation; regulation of phosphoinositide 3-kinase activity
Research Articles on PIK3R6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with PIK3R6 active protein
| Products by Pathway | Pathway Diagram |
|---|---|
| 3-phosphoinositide Biosynthesis Pathway antibodies | 3-phosphoinositide Biosynthesis Pathway Diagram |
| 3-phosphoinositide Biosynthesis Pathway antibodies | 3-phosphoinositide Biosynthesis Pathway Diagram |
| G Beta:gamma Signalling Through PI3Kgamma Pathway antibodies | G Beta:gamma Signalling Through PI3Kgamma Pathway Diagram |
| G-protein Beta:gamma Signalling Pathway antibodies | G-protein Beta:gamma Signalling Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPVI-mediated Activation Cascade Pathway antibodies | GPVI-mediated Activation Cascade Pathway Diagram |
| Hemostasis Pathway antibodies | Hemostasis Pathway Diagram |
| Metabolism Pathway antibodies | Metabolism Pathway Diagram |
| Metabolism Of Lipids And Lipoproteins Pathway antibodies | Metabolism Of Lipids And Lipoproteins Pathway Diagram |
| PI Metabolism Pathway antibodies | PI Metabolism Pathway Diagram |