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> Polymyxin B (Sulfate) [1405-20-5]

Polymyxin B (Sulfate) [1405-20-5]

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Référence HY-A0248-1g

Conditionnement : 1g

Marque : MedChemExpress


Description

Polymyxin B Sulfate is a potent antibacterial agent and a relatively toxic antibiotic. Polymyxin B Sulfate also is a antiendotoxin agent. Polymyxin B Sulfate shows endotoxin-neutralizing properties can be used as adjunctive research in gram-negative sepsis. Polymyxin B Sulfate shows antibacterial activities in vitro and in vivo[1][2][3].

In Vitro

Polymyxin B Sulfate shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polymyxin B Sulfate Related Antibodies
In Vivo

Polymyxin B Sulfate (0.5-120 mg/kg; s.c.) shows antibacterial activities in thigh or lung infection mouse model[2].
Polymyxin B Sulfate (2 mg/kg, s.c.) shows potent in mouse bactericidal effect against E. coli strain IH3080[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old, 24-30 g, female Swiss mice[2]
Dosage: 0.5-120 mg/kg for thigh infection model; 5-120 mg/kg for lung infection mode
Administration: S.c.
Result: Showed antibacterial activities for three K. pneumoniae strains.
Animal Model: 7-9 weeks, female NMRI mice (E. coli IH3080)[3]
Dosage: 2 mg/kg
Administration: S.c.
Result: Decreased the bacterial count in a dose dependent manner.
Masse moléculaire

1199.75 (average)

CAS No.
Appearance

Solid

Color

White to off-white

Structure Classification
Initial Source

Bacillus polymyxa
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité
In Vitro: 

H2O : 116.67 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation
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