Conditionnement : 50mg
Synonyms:
| Description | Pro8-Oxytocin, a modified oxytocin (OXT) ligand, elicits more potent and efficacious responses at primate OXTR and induces stronger behavioral effects compared to the standard mammalian OXT ligand (Leu8-Oxytocin). It demonstrates lower efficacy than Vasopressin (AVP) at human AVPR1a, yet shows a higher efficacious response at marmoset AVPR1a [1]. |
| In vitro | Pro8-Oxytocin, at concentrations ranging from 1 nM to 10 μM, is capable of inducing calcium mobilization in CHO cells expressing the AVPR1a receptor [1]. |
| In vivo | Pro8-Oxytocin exhibits higher binding affinity for the primate oxytocin receptor (OXTR) than Leu8-Oxytocin, particularly in primates expressing Pro8-OXT and Leu8-OXT, resulting in a more potent calcium signaling response [1]. |
| Molecular Weight | 991.14 |
| Formula | C42H62N12O12S2 |
| Cas No. | 24327-19-3 |
| Smiles | C(=O)([C@H]1N(C(=O)[C@H]2NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@@H](N)CSSC2)12)CCC1)N4[C@H](C(NCC(N)=O)=O)CCC4 |
| Sequence | Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Pro-Gly-NH₂ (Disulfide bridge:Cys1-Cys6) |
| Sequence Short | CYIQNCPPG |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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