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Prostaglandin E1 [745-65-3]

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Référence NB-64-07339-1mg

Conditionnement : 1mg

Marque : Neo Biotech

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Prostaglandin E1

(Synonyms: PGE1, Alprostadil) Copy Product Info

Synonyms: PGE1, Alprostadil

Catalog No. T1626 Copy Product Info

Purity: 99.93%

Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP.

Cas No. 745-65-3

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.93%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP.
Synonyms	PGE1, Alprostadil

Chemical Properties

Molecular Weight	354.48
Formula	C₂₀H₃₄O₅
Cas No.	745-65-3
Smiles	CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O
Relative Density.	1.0458 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (282.1 mM)

H2O: <1 mg/mL (insoluble)

Ethanol: 100 mg/mL (282.1 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3 mg/mL (8.46 mM)

10% DMSO+90% PBS: 3 mg/mL (8.46 mM)

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8210 mL	14.1052 mL	28.2103 mL	141.0517 mL
5 mM	0.5642 mL	2.8210 mL	5.6421 mL	28.2103 mL
10 mM	0.2821 mL	1.4105 mL	2.8210 mL	14.1052 mL
20 mM	0.1411 mL	0.7053 mL	1.4105 mL	7.0526 mL
50 mM	0.0564 mL	0.2821 mL	0.5642 mL	2.8210 mL
100 mM	0.0282 mL	0.1411 mL	0.2821 mL	1.4105 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

vasodilatorvasodilationprostanoidProstaglandinReceptorProstaglandin ReceptorProstaglandin E-1Prostaglandin E1Prostaglandin E 1plateletPGE-1PGE 1PGEInhibitorinhibitEP4EP3EP2EP1EndogenousMetaboliteEndogenous Metaboliteaggregation

Related Tags: Prostaglandin E1 chemical structure | Prostaglandin E1 formula | Prostaglandin E1 molecular weight