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Puromycin [53-79-2]

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Référence NB-64-09791-5mg

Conditionnement : 5mg

Marque : Neo Biotech

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Puromycin

(Synonyms: Puromycine, NSC-3055, NSC3055, NSC 3055) Copy Product Info

Synonyms: Puromycine, NSC-3055, NSC3055, NSC 3055

Catalog No. T19978 Copy Product Info

Puromycin (NSC-3055) is an antibiotic protein synthesis inhibitor. It inhibits protein synthesis by binding to RNA. It also serves as an anticancer drug by suppressing the growth and metastasis in esophagus cancer cells by Akt phosphorylation. It is an antineoplastic and antitrypanosomal agent and is used in research as an inhibitor of protein synthesis.

Cas No. 53-79-2

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:>99.99%

Product Introduction

Bioactivity

Description	Puromycin (NSC-3055) is an antibiotic protein synthesis inhibitor. It inhibits protein synthesis by binding to RNA. It also serves as an anticancer drug by suppressing the growth and metastasis in esophagus cancer cells by Akt phosphorylation. It is an antineoplastic and antitrypanosomal agent and is used in research as an inhibitor of protein synthesis.
Synonyms	Puromycine, NSC-3055, NSC3055, NSC 3055

Chemical Properties

Molecular Weight	471.51
Formula	C₂₂H₂₉N₇O₅
Cas No.	53-79-2
Smiles	COc1ccc(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)n2cnc3c(ncnc23)N(C)C)cc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (212.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (10.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1208 mL	10.6042 mL	21.2085 mL	106.0423 mL
5 mM	0.4242 mL	2.1208 mL	4.2417 mL	21.2085 mL
10 mM	0.2121 mL	1.0604 mL	2.1208 mL	10.6042 mL
20 mM	0.1060 mL	0.5302 mL	1.0604 mL	5.3021 mL
50 mM	0.0424 mL	0.2121 mL	0.4242 mL	2.1208 mL
100 mM	0.0212 mL	0.1060 mL	0.2121 mL	1.0604 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Keywords

Puromycinantibiotic

Related Tags: Puromycin chemical structure | Puromycin formula | Puromycin molecular weight