- Specifications
Product Description
Mouse monoclonal antibody raised against partial recombinant RB1.
Immunogen
Recombinant protein corresponding to amino acids 387-928 of human RB1.
Host
Mouse
Reactivity
Chicken, Human, Mouse
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Immunofluorescence
Immunoprecipitation
Western Blot
- Gene Info — RB1
Entrez GeneID
5925Gene Name
RB1
Gene Alias
OSRC, RB, p105-Rb, pRb, pp110
Gene Description
retinoblastoma 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq
Other Designations
OTTHUMP00000018397|retinoblastoma suspectibility protein|retinoblastoma-associated protein
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.
Hu QJ, Bautista C, Edwards GM, Defeo-Jones D, Jones RE, Harlow E.
Molecular and Cellular Biology 1991 Nov; 11(11):5792.
Application：Func, IP, Chicken, Human, Mouse, Chicken embryo fibroblasts, ML-1, NS-1 cells.
- Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.
RB1 monoclonal antibody, clone XZ55
Référence MAB2010
Conditionnement : 100ug