Recombinant Animal Free Human IL-21 Protein
Référence MBS206840-0,01mg
Conditionnement : 0.01mg
Marque : MyBiosource
3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain
Human IL-21 stimulates IFN-gamma secretion of the NK-92 human natural killer cells. The ED50 range <= 4 ng/ml.
IL-21 Animal Free Human Active Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206840IL-21, also known as Interleukin-21, is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumor responses. It has broad immunoregulatory activity and can modulate both humoral and cell-mediated responses. It is important in the… More details
Product Overview
Online Datasheet in PDFProduct Name
IL-21, Active Protein
Full Product Name
Recombinant Animal Free Human IL-21 Protein
Product Gene Name
IL-21 active protein
Product Synonym Names
Interleukin-21
Sequence
MQGQDRHMIR MRQLIDIVDQ LKNYVNDLVP EFLPAPEDVE TNCEWSAFSC FQKAQLKSAN GNNERIINV SIKKLKRKPP STNAGRRQKH RLTCPSCDSY EKKPPKEFLE RFKSLLQKMI HQHLSSRTHG SEDS
Host
E coli
Form/Format
Liquid in. Phosphate-Buffered Saline (pH7.4)
Purity/Purification
> 95% by SDS-PAGE
Concentration
0.25mg/ml (determined by absorbance at 280nm) (lot specific)
Preparation and Storage
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
18 kDa
Sequence Positions
30-162aa
OMIM
605384
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Product Categories/Family for IL-21 active protein
Signal Transduction, Hormones & Cytokines; Proteins
Applications Tested/Suitable for IL-21 active protein
SDS-PAGE (SDS), Bioactivity
Product References and Citations for IL-21 active protein
Gui G., et al. (2017) Clin Immunol. 183:266-272.
Parrish-Novak J., et al. (2000) Nature. 408(6808):57-63.
Parrish-Novak J., et al. (2000) Nature. 408(6808):57-63.
Other Notes
Small volumes of IL-21 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for IL-21 purchase
MBS206840 is an active protein targeting IL-21. Also known as Recombinant Animal Free Human IL-21 Protein. Host: E coli.
Additional Details
NCBI/Uniprot data below describe general gene information for IL-21. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-21 isoform 1
NCBI Official Synonym Full Names
interleukin 21
NCBI Official Symbol
IL21
NCBI Official Synonym Symbols
Za11; IL-21; CVID11
UniProt Protein Name
Interleukin-21
UniProt Synonym Protein Names
Za11
UniProt Gene Name
IL21
UniProt Synonym Gene Names
IL-21
UniProt Entry Name
IL21_HUMAN
NCBI Protein Information
interleukin-21; interleukin-21 isoform
NCBI Summary for IL-21
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Show more UniProt Comments for IL-21
IL21: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Secreted, signal peptide; Secreted; Cytokine; Cell development/differentiation
Chromosomal Location of Human Ortholog: 4q26-q27
Cellular Component: extracellular space
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding; cytokine activity
Biological Process: positive regulation of interleukin-17 production; positive regulation of natural killer cell cytokine production; cell maturation; signal transduction; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of interleukin-10 production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tissue remodeling; positive regulation of cell proliferation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; immune response; positive regulation of interferon-gamma biosynthetic process; positive regulation of inflammatory response
Disease: Immunodeficiency, Common Variable, 11
Show more Protein type: Apoptosis; Secreted, signal peptide; Secreted; Cytokine; Cell development/differentiation
Chromosomal Location of Human Ortholog: 4q26-q27
Cellular Component: extracellular space
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding; cytokine activity
Biological Process: positive regulation of interleukin-17 production; positive regulation of natural killer cell cytokine production; cell maturation; signal transduction; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of interleukin-10 production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tissue remodeling; positive regulation of cell proliferation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; immune response; positive regulation of interferon-gamma biosynthetic process; positive regulation of inflammatory response
Disease: Immunodeficiency, Common Variable, 11
Research Articles on IL-21
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with IL-21 active protein
| Reference Product | PubMed Publications |
|---|---|
| IL21R active protein | >372 publications with IL-21 and IL21R |
| STAT3 active protein | >117 publications with IL-21 and STAT3 |
| IL15 active protein | >83 publications with IL-21 and IL15 |
| IL4 active protein | >14 publications with IL-21 and IL4 |
| IL13 active protein | >6 publications with IL-21 and IL13 |
| IL9 active protein | >5 publications with IL-21 and IL9 |
| IL7 active protein | >4 publications with IL-21 and IL7 |
| NFATC2 active protein | >1 publications with IL-21 and NFATC2 |
| TSLP active protein | >1 publications with IL-21 and TSLP |
Pathways associated with IL-21 active protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Inflammatory Bowel Disease (IBD) Pathway antibodies | Inflammatory Bowel Disease (IBD) Pathway Diagram |
| Inflammatory Bowel Disease (IBD) Pathway antibodies | Inflammatory Bowel Disease (IBD) Pathway Diagram |
| Jak-STAT Signaling Pathway antibodies | Jak-STAT Signaling Pathway Diagram |
| Jak-STAT Signaling Pathway antibodies | Jak-STAT Signaling Pathway Diagram |
Diseases associated with IL-21 active protein
| Disease Name | Pubmed Publications |
|---|---|
| Autoimmune Diseases Antibodies | >270 publications with IL-21 and Autoimmune Diseases |
| Inflammation Antibodies | >175 publications with IL-21 and Inflammation |
| Disease Models, Animal Antibodies | >119 publications with IL-21 and Disease Models, Animal |
| Lupus Erythematosus, Systemic Antibodies | >72 publications with IL-21 and Lupus Erythematosus, Systemic |
| Necrosis Antibodies | >64 publications with IL-21 and Necrosis |
| Liver Diseases Antibodies | >44 publications with IL-21 and Liver Diseases |
| Celiac Disease Antibodies | >32 publications with IL-21 and Celiac Disease |
| Hypersensitivity Antibodies | >29 publications with IL-21 and Hypersensitivity |
| Kidney Diseases Antibodies | >28 publications with IL-21 and Kidney Diseases |
| Heart Diseases Antibodies | >16 publications with IL-21 and Heart Diseases |
Organs/Tissues associated with IL-21 active protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Uncharacterized Tissue Antibodies | >1 publications with IL-21 and Uncharacterized Tissue |