Recombinant Bovine Bos d 8 (E. coli)
Référence DRA119-1mg
Conditionnement : 1mg
Marque : Novoprotein
Description Recombinant Bovine Bos d 8 is produced by our E.coli expression system and the target gene encoding Arg16-Trp214 is expressed with a 6His tag at the N-terminus.
Accession P02662
Known As Alpha-S1-casein; Bos d 8; CSN1S1
Mol Mass 24.5 kDa
APMol Mass 33 kDa, reducing conditions
Formulation Description Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 0.01% Tween 80, 1mM EDTA, 50% Glycerol, pH8.0.
Purity-SDS-PAGE 
Greater than 95% as determined by reducing SDS-PAGE. (QC verified) Bioactivity Data 0
Storage - Reconstituted protein solution should be stored at ≤ -20°C.
- Stable for at least 24 months when stored as instructed.
Shipping The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Background Milk is one of the first food components introduced into the diet and therefore represents one of the most important food allergen sources in terms of frequency and severity of allergic manifestations. The symptoms of cow’s milk allergy are due to IgE-mediated activation of mast cells and basophils as well as to activation of allergen-specific T cells, and they comprise a plethora of gastrointestinal, skin, respiratory, and severe systemic manifestations such as death due to anaphylactic shock. Cow’s milk contains 25 different proteins, but only the whey proteins α-lactalbumin, β-lactoglobulin, BSA, and lactoferrin, as well as the four caseins, have been identified as allergens. The casein fraction is composed of α-S1-,α-S2-,β-, and k-casein, of which αS1-casein seems to be a major allergen according to IgE and T cell recognition data.