Recombinant Human IFN-α 1b (E. coli)

Biological Activity

IFN-alpha 1b (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway, exerts function by inhibiting viral replication as well as modulating immune response.

Recombinant Human IFN-α 1b expressed the target gene encoding Cys24-Glu189 (Ala137Val).

The specific activity determined by an anti-viral assay is no less than 1.0 × 10⁸ IU/mg.

Accession: P01562

Apparent Molecular Weight: 19.5 kDa

Endotoxin < 1 EU/µg

Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4, 4% mannitol, 1% HSA.

Chemical Information

Form	Lyophilized powder
Solubility (25°C)	Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
Storage	Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.

References

[1] Songying Ouyang, et al. J Mol Med (Berl). Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus

[2] Wang-Long Chuang, et al. Intervirology. Treatment of chronic hepatitis C in southern Taiwan

[3] H S Panitch. Mult Scler. Early treatment trials with interferon beta in multiple sclerosis

[4] E C O'Rourke, et al. Mol Cell Biol. Binding of 125I-labeled recombinant beta interferon (IFN-beta Ser17) to human cells