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S-Adenosyl-L-methionine disulfate tosylate [97540-22-2]

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Référence NB-64-35484-100mg

Conditionnement : 100mg

Marque : Neo Biotech

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S-Adenosyl-L-methionine disulfate tosylate

(Synonyms: Ademetionine disulfate tosylate) Copy Product Info

Synonyms: Ademetionine disulfate tosylate

Catalog No. T6752 Copy Product Info

Purity: 99.98%

S-Adenosyl-L-methionine disulfate tosylate is a methyl donor with oral activity. S-Adenosyl-L-methionine disulfate tosylate is a dietary supplement with effective antidepressant and pain-relieving effects. S-Adenosyl-L-methionine disulfate tosylate also has anti-proliferative, pro-apoptotic and anti-metastatic effects in cancer. S-Adenosyl-L-methionine can be used in the research of liver diseases and osteoarthritis.

Cas No. 97540-22-2

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Color:White to Yellow

Product Introduction

Bioactivity

Description	S-Adenosyl-L-methionine disulfate tosylate is a methyl donor with oral activity. S-Adenosyl-L-methionine disulfate tosylate is a dietary supplement with effective antidepressant and pain-relieving effects. S-Adenosyl-L-methionine disulfate tosylate also has anti-proliferative, pro-apoptotic and anti-metastatic effects in cancer. S-Adenosyl-L-methionine can be used in the research of liver diseases and osteoarthritis.
In vitro	METHODS: Cal-33 and JHU-SCC-011 cells were treated with S-Adenosyl-L-methionine disulfate tosylate (300 µM) for 24 or 48 hours. Apoptosis and cell cycle were detected by flow cytometry. Cell migration was detected using the Scratch-wound assay. RESULTS: S-Adenosyl-L-methionine disulfate tosylate induces apoptosis and promotes cell cycle arrest in Cal-33 and JHU-SCC-011 cells, reducing the migration of Cal-33 and JHU-SCC-011 cells. [1] METHODS: Human A549 lung cancer cells were treated with S-Adenosyl-L-methionine disulfate tosylate (5-40 μg/mL) for 48 hours, and the DNMTs protein level was detected by Western Blot method. RESULTS: S-Adenosyl-L-methionine disulfate tosylate protects the anti-cancer effect of 5-FU by regulating the expression of DNMTs. [2]
In vivo	METHODS: To investigate the effect of S-Adenosyl-L-methionine disulfate tosylate on ASD, S-Adenosyl-L-methionine disulfate tosylate (30 mg/kg) was administered orally to young rats for 3 days. RESULTS: S-Adenosyl-L-methionine disulfate tosylate could prevent ASD-like behaviors induced by valproic acid exposure early after birth in young rats. [3] METHODS: To study the antiepileptic effect of S-Adenosyl-L-methionine disulfate tosylate, S-Adenosyl-L-methionine disulfate tosylate (50 mg/kg, 100 mg/kg) was orally administered to pentylenetetrazole-induced epilepsy rats. RESULTS: S-Adenosyl-L-methionine disulfate tosylate exhibited antiepileptic, memory enhancement and antioxidant properties in pentylenetetrazole-induced epilepsy rats. [4]
Synonyms	Ademetionine disulfate tosylate

Chemical Properties

Molecular Weight	766.8
Formula	C₂₂H₃₄N₆O₁₆S₄
Cas No.	97540-22-2
Smiles	OS(O)(=O)=O.OS(O)(=O)=O.CC1=CC=C(C=C1)S(O)(=O)=O.C[S+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12
Relative Density.	no data available

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 72 mg/mL (93.9 mM), Sonication is recommended.

DMSO: 247.5 mg/mL (322.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (6.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3041 mL	6.5206 mL	13.0412 mL	65.2061 mL
5 mM	0.2608 mL	1.3041 mL	2.6082 mL	13.0412 mL
10 mM	0.1304 mL	0.6521 mL	1.3041 mL	6.5206 mL
20 mM	0.0652 mL	0.3260 mL	0.6521 mL	3.2603 mL
50 mM	0.0261 mL	0.1304 mL	0.2608 mL	1.3041 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0130 mL	0.0652 mL	0.1304 mL	0.6521 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

S-Adenosyl-L-methionine disulfate TosylateSAdenosylLmethionine disulfate tosylateS-Adenosyl methionine disulfateS Adenosyl L methionine disulfate tosylateRNASynthesisRNA SynthesisInhibitorinhibitDNASynthesisDNA SynthesisAPE1(Ref-1)AdoMet disulfateAdemetionine disulfate TosylateAdemetionine disulfate

Related Tags: S-Adenosyl-L-methionine disulfate tosylate chemical structure | S-Adenosyl-L-methionine disulfate tosylate in vivo | S-Adenosyl-L-methionine disulfate tosylate in vitro | S-Adenosyl-L-methionine disulfate tosylate formula | S-Adenosyl-L-methionine disulfate tosylate molecular weight