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> S100B Protein, Mouse, Recombinant (His)

S100B Protein, Mouse, Recombinant (His)

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Référence NB-64-53312-50ug

Conditionnement : 50ug

Marque : Neo Biotech


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S100B Protein, Mouse, Recombinant (His)

(Synonyms: S100b, S100 β, S-100 protein β chain, S-100 protein subunit β, S-100 protein subunit beta, S-100 protein beta chain, S100 calcium-binding protein B, S100 calcium binding protein B, S100 beta, Protein S100-B) Copy Product Info

Synonyms: S100b, S100 β, S-100 protein β chain, S-100 protein subunit β, S-100 protein subunit beta, S-100 protein beta chain, S100 calcium-binding protein B, S100 calcium binding protein B, S100 beta, Protein S100-B

Catalog No. TMPJ-00990 Copy Product Info
Purity: 99%
S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal fluid in brain damage and then into the blood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS, and the astrocytes are the major cells producing S100-B protein in gray matter, as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs. In addition, S100-B, which is also present in Mouse melanocytes, is a reliable marker for melanoma malignancy both in bioptic tissue and in serum.
Other Forms of S100B Protein, Mouse, Recombinant (His):
S100B Protein, Canine, Recombinant (hFc)
S100B Protein, Human, Recombinant (hFc)
S100B Protein, Human, Recombinant (His)
S100B Protein, Mouse, Recombinant (hFc)
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99%
Appearance:Lyophilized powder
Color:White
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Product Introduction

Bioactivity
Bioactivity
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal fluid in brain damage and then into the blood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS, and the astrocytes are the major cells producing S100-B protein in gray matter, as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs. In addition, S100-B, which is also present in Mouse melanocytes, is a reliable marker for melanoma malignancy both in bioptic tissue and in serum.
Species
Mouse
Expression System
E. coli
TagC-6xHis
Accession NumberP50114
Amino AcidMet1-Glu92
ConstructionMet1-Glu92
Protein Purity
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
S100B Protein, Mouse, Recombinant (His)
Endotoxin< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
ReconstitutionReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
SynonymsS100b, S100 β, S-100 protein β chain, S-100 protein subunit β, S-100 protein subunit beta, S-100 protein beta chain, S100 calcium-binding protein B, S100 calcium binding protein B, S100 beta, Protein S100-B
Research Background
S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal fluid in brain damage and then into the blood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS, and the astrocytes are the major cells producing S100-B protein in gray matter, as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs. In addition, S100-B, which is also present in Mouse melanocytes, is a reliable marker for melanoma malignancy both in bioptic tissue and in serum.
Chemical Properties
Molecular Weight12 KDa (reducing condition)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageLyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

S-100 protein b chain
Related Tags: S100B Protein, Mouse, Recombinant (His) chemical structure | S100B Protein, Mouse, Recombinant (His) molecular weight