SQSTM1 Mouse Monoclonal Antibody [Clone ID: OTI1E9]
Référence TA502127
Conditionnement : 100ul
SQSTM1 Mouse Monoclonal Antibody [Clone ID: OTI1E9]
SKU
TA502127
SQSTM1 mouse monoclonal antibody, clone OTI1E9 (formerly 1E9)
| Product Data | |
| Clone Name | OTI1E9 |
|---|---|
| Application | FC, IF, IHC, WB |
| Recommended Dilution | WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human SQSTM1 (NP_003891) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 0.86 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 47.5 kDa |
| Gene Name | sequestosome 1 |
| Database Link | |
| Background | This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. provided by RefSeq, Mar 2009 |
| Synonyms | A170; OSIL; p60; p62; p62B; PDB3; ZIP3 |
| Note | WB application: Only overexpression results are guaranteed, not endogenous |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Nervous system: Neurodegenerative diseases |
| Protein Families | Druggable Genome, Transcription Factors |
| Product Manuals |
| FAQs |
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| SDS |
| Antibody Resources |
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| SKU | Description | Size | ||
|---|---|---|---|---|
| TA502127S | SQSTM1 mouse monoclonal antibody, clone OTI1E9 (formerly 1E9) | 30 ul | | |
Citations
Fangchinoline suppresses hepatocellular carcinoma by regulating ROS accumulation via the TRIM7/Nrf2 signaling pathway
Liu, Wang, Wang et al
Phytomedicine (2024) 135, 156143 DOI: 10.1016/j.phymed.2024.156143
Liu, Wang, Wang et al
Phytomedicine (2024) 135, 156143 DOI: 10.1016/j.phymed.2024.156143
Cited by 19
AI Summary: OriGene contributed to this study by providing the mouse anti-SQSTM1/p62 antibody (TA502127), which was used to investigate protein expression related to the mechanisms by which Fangchinoline suppresses hepatocellular carcinoma.
Snippet: The mouse anti-SQSTM1/p62 (TA502127, 1:1000) antibody was purchased from OriGene (Maryland, USA). The rabbit anti-P-ULK1 (Ser757) (14,202, 1:1000) antibody was ordered from Cell Signaling Technology (Massachusetts, USA). The rabbit anti-MKI67/Ki67 (ab15580, 1:500) and anti-PCNA (1:500, ab18197) antibodies were purchased from Abcam (Cambridge,
Deacetylation of GLUD1 maintains the survival of lung adenocarcinoma cells under glucose starvation by inhibiting autophagic cell death
Hu, Sun, Cheng et al
Cell Insight (2024) 3 (5), 100186 DOI: 10.1016/j.cellin.2024.100186
Hu, Sun, Cheng et al
Cell Insight (2024) 3 (5), 100186 DOI: 10.1016/j.cellin.2024.100186
Cited by 11
Snippet: The mouse monoclonal antibody against SQSTM1/p62 monoclonal antibody (TA502127,1:2000);The rabbit polyclonal antibody against P-ULK1 (TA383093, 1:1000) were ordered from OriGene. The anti-Acetyllysine mouse mAb (PTM-101, 1:1000) were ordered from PTM BIO
FAIM regulates autophagy through glutaminolysis in lung adenocarcinoma
Han, Wang, Wang et al
Autophagy (2021)
Han, Wang, Wang et al
Autophagy (2021)
Cited by 22
AI Summary: In this study, OriGene products including FAIM1 siRNA (SR305093) and FAIM1 overexpression plasmid (RC213674) were used to manipulate FAIM1 expression levels, enabling the authors to investigate FAIM's role in regulating autophagy and glutaminolysis in lung adenocarcinoma cells.
Snippet: …FAIM/FAIM1 (Fas apoptotic inhibitory molecule) is known as an important anti-apoptotic protein, but little is known about its function in tumorigenesis. Here, we found that knocking down FAIM induced macroautophagy/autophagy through suppressing the activation of the MTOR pathway in lung adenocarcinoma. Further studies demonstrated that FAIM could promote the tetramer formation of GAC through increasing PRKCE/PKCε-mediated phosphorylation. What's more, FAIM also stabilized GAC through sequestering GAC from degradation by protease ClpXP. … Besides, FAIM also promoted the association of ULK1 and MTOR and this further suppressed autophagy induction. These findings discovered new functions of FAIM and elucidated an important molecular mechanism for GAC in maintaining its high enzymatic activity and protein stability
TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1
Han, Guo, Gan et al
Autophagy (2018) 14 (12), 2035-2048 DOI: 10.1080/15548627.2018.1491493
Han, Guo, Gan et al
Autophagy (2018) 14 (12), 2035-2048 DOI: 10.1080/15548627.2018.1491493
AI Summary: In this study, the OriGene product pCMV6-AC-GFP-TRIM59 plasmid (PS100010) was used to investigate the role of TRIM59 in regulating autophagy through its effects on BECN1 transcription and ubiquitination.
Snippet: … RESEARCH PAPER - BASIC SCIENCE TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1 Tianyu Hana,b, Meng Guoa, Mingxi Gana, Bentong Yuc, Xiaoli Tianb, and Jian-Bin Wanga;The plasmid pcDNA3.1-FLAG-PIK3C3 was kindly provided by Dr. Qimin Zhan (Chinese Academy of Medical Sciences and Peking Union Medical College). The plasmid pCMV6-AC-GFP-TRIM59 was purchased from OriGene (PS100010). The mutant plasmids (BECN1-K117R, BECN1-E299A) were made by Generay Biotech
A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway
Han, Guo, Zhang et al
Oncotarget (2017) 8 (17), 28063-28073 DOI: 10.18632/oncotarget.14188
Han, Guo, Zhang et al
Oncotarget (2017) 8 (17), 28063-28073 DOI: 10.18632/oncotarget.14188
Snippet: SQSTM1/p62 and Beclin1 mouse monoclonal antibodies were ordered from OriGene (TA502127, TA502127)
Showing 1-5 of 5 papers.
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